Human pharmacology : molecular to clinical / Theodore M. Brody, Joseph Larner, Kenneth P. Minneman.

Includes bibliographical references and index.

Contents

Part I: General Principles.
1.Introduction and Definitions.
2.Sites of Action: Receptors.
3.Concentration-Response Relationships.
4.Absorption, Distribution, Metabolism and Elimination.
5.Clinical Pharmacokinetics and Dosing Schedules.
6.Gene Therapy.
7.Issues in Therapeutics.

Part II: Peripheral Nervous System: Drugs Affecting Transmission and Function.
8.Physiology and Biochemistry of the Peripheral Autonomic Nervous System.
9.Drugs Affecting the Parasympathetic Nervous System and Autonomic Ganglia.
10.Drugs Affecting the Sympathetic Nervous System.
11.Neuromuscular Blocking Agents.
12.Drugs Affecting Peripheral Transmission: Local Anesthetics.
13.5-Hydroxytryptamine (Serotonin) and Therapeutic Agents that Modulate Serotonergic Neurotransmission.

Part III: Cardiovascular System: Drugs Affecting Cardiac Function, Blood Pressure, Renal Function, And Coagulation.
14.Regulation of Blood Pressure By the Autonomic Nervous System.
15.Antihypertensive Drugs.
16.Cardiac Electrophysiology and Antiarrhythmic Agents.
17.Drugs to Treat Heart Failure, Cardiac Glycosides.
18.Calcium Antagonists.
19.Vasodilators and Nitric Oxide Synthase.
20.Prostaglandins and Related Autocoids.
21.Diuretics: Drugs that Increase the Excretion of Water and Electrolytes.
22.Lipid-Lowering Drugs and Atherosclerosis.
23.Drugs Affecting Coagulation, Fibrinolysis, And Platelet Aggregation.

Part IV: Drugs Affecting Behaviour, Psychotic State, Pain Sensation, Muscle Control, And Sleep.
24.Pharmacological Organization of the CNS.
25.Antipsychotic Agents.
26.Drugs for the Treatment of Affective (Mood) Disorders.
27.Drugs to Treat Anxieties and Related Disorders.
28.Drugs for Seizure Disorders (Epilepsies).
29.Drugs for the Treatment of Movement Disorders.
30.Pain Control with Opioid Analgesics.
31.Pain and Inflammation Control with Nonsteroidal Antiinflammatory Drugs.
32.Pain Control with General Anesthetics.
33.Alcohol.
34.Drug Abuse.
35.Drugs for Sleep Disorders.

Part V: Endocrine Systems: Hormones and Related Compounds.
36.Hormone Receptors and Signaling Mechanisms.
37.Glucocorticoids and Mineralcorticoids.
38.Estrogens, Progestins and Contraceptives.
39.Androgens and Antiandrogens.
40.Thyroid and Antithyroid Drugs.
41.Insulin and Oral Hypoglycemic Agents.
42.Drugs Affecting Uterine Motility.
43.Hypothalamic-Pituitary Hormones.
44.Calcium-Regulating Hormones and Other Agents Affecting Bone.

Part VI: Neoplastic Cells: Drugs Affecting Cell Growth and Viability
45.Individual Antineoplastic Drugs.
46.Clinical Effects with Antineoplastic Drugs.
47.Immunopharmacology.

Part VII: Invading Organisms: Agents that Kill Invaders
48.Principles of Antimicrobial Use.
49.Bacterial Cell Wall Inhibitors.
50.Inhibitors of Bacterial Ribosomal Actions.
51.Bacterial Folate Antagonists.
52.Other Antibacterial Agents.
53.Selection of an Antibacterial Agent.
54.Antimycobacterial Agents.
55. Antifungal Agents.
56.Antiviral Agents.
57Drugs Effective Against Parasitic Helminthic Infections.
58.Drugs Effective Against Parasitic Protozoal Infections.
59.Antiseptics and Disinfectants.

Part VIII: Other Systems and Special Topics
60.Drugs Used in Asthma and Obstructive Lung Disease.
61.Histamine and Antihistamines.
62.Gastrointestinal Drugs.
63.Nutritional Aspects of Pharmacology.
64.Toxicology.
65.Perinatal/Neonatal Pharmacology.
66.Gerontological Pharmacology.
67.Drugs to Treat Anemia.
68.Regulated Drug Development and Usage.
Appendices