Therapeutics, evidence and decision-making / Michael D. Rawlins ; foreword by Parveen J. Kumar.

Contents;

Section 1: Introduction
1.1 The nature of evidence
1.2 Probability
1.3 Clinical endpoints of benefits and harms
1.4 Statistical expressions of benefit and harm
1.5 Bias and confounding
etc.

Section 2: Randomized controlled trials
2.1 General principles
2.2 Stopping rules
2.3 Analysis of subgroups
2.4 Safety
2.5 Generalizability

Section 3: Observational studies
3.1 General overview
3.2 Historical controlled trials
3.3 Concurrent cohort studies
3.4 Case - control designs
3.5 Databases
etc.

Section 4: Qualitative research
4.1 Approaches and methods
4.2 Uses in the evaluation of therapeutic interventions

Section 5: Economic evaluation
5.1 General principles
5.2 Cost effectiveness, cost - utility and cost - minimization analyses
5.3 Cost - consequences analysis

Section 6: Decision-making
6.1 For individuals
6.2 For populations

Includes bibliographical references and index.