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Metabolic polymorphisms and susceptibility to cancer / edited by Paolo Vineis ... [et al.].

Contributor(s): Series: IARC scientific publications ; no. 148Publication details: Lyon, France : International Agency for Research on Cancer ; Carey, NC : Distributed by Oxford University Press, 1999.Description: xii, 510 p. : ill. ; 24 cmISBN:
  • 9283221486
Subject(s): DDC classification:
  • QZ 200 M587 1999 21 M587 1999
LOC classification:
  • RC268.4 .M48 1999
Online resources:
Contents:
Part 1. General Aspects of the Study of Metabolic Polymorphisms 1. Why to study metabolic susceptibility to cancer 2. A nomenclature system for metabolic gene polymorphisms 3. Metabolism of xenobiotics and chemical carcinogenesis 4. Selection of candidate genes for popylation studies 5. Somatic alterations and metabolic polymorphisms Part 2. Methodological Issues 6. Strategic issues in the design and interpretation of studies on metabolic polymorphisms and cancer susceptibility 7. Inherent difficulties in epidemiological studies involving phenotyping, 8. Xenobiotic-metabolizing enzymes and cancer risk: Correspondence between genotype and phenotype 9. The impact of misclassification in case-control studies of gene-environmental interaction 10. Epidemiological studies on genetics polymorphisms: Study design issues and measures of occurrence and associationa 11. Interaction, subgroup analysis, and sample size 12. Design and analysis issues in genetic case-control studies Part 3. Role of Specific Enzymes in Cancer Susceptibility 13. Laboratory methods for the determination of genetic polymorphisms in humans 14. Ah receptor gene polymorphisms and human cancer susceptibility 15. CYP1A1 16. Human cytochrome P4501A2 17. CYP2A subfamily: function, expression and genetic polymorphisms 18. Cytochrome P450 CYP2D6 19. Glutation-S-Transferases: influence of polymorphisms on cancer susceptibility 20. Polymorphic NAT's and cancer predisposition 21. Additional metabolic polymorphisms 22. Interaction between detoxifying enzyme polymorphisms and susceptibility to cancer 23. Review of studies of selected metabolic polymorphisms and cancer Part 4. Prospects and implications 24. Genetics analysis of metabolic polymorphisms in molecular epidemiological studies; social and ethical implications 25. Conclusions and research perspectives
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Item type Current library Call number Copy number Status Date due Barcode
Book Open Access Book Open Access Health Sciences Library QZ 200 M587 1999 (Browse shelf(Opens below)) 1 Available MBAL22010666

Includes bibliographical references and index.

Part 1. General Aspects of the Study of Metabolic Polymorphisms


1. Why to study metabolic susceptibility to cancer


2. A nomenclature system for metabolic gene polymorphisms


3. Metabolism of xenobiotics and chemical carcinogenesis

4. Selection of candidate genes for popylation studies

5. Somatic alterations and metabolic polymorphisms


Part 2. Methodological Issues


6. Strategic issues in the design and interpretation of studies on metabolic polymorphisms and cancer susceptibility


7. Inherent difficulties in epidemiological studies involving phenotyping,


8. Xenobiotic-metabolizing enzymes and cancer risk: Correspondence between genotype and phenotype


9. The impact of misclassification in case-control studies of gene-environmental interaction


10. Epidemiological studies on genetics polymorphisms: Study design issues and measures of occurrence and associationa


11. Interaction, subgroup analysis, and sample size


12. Design and analysis issues in genetic case-control studies


Part 3. Role of Specific Enzymes in Cancer Susceptibility


13. Laboratory methods for the determination of genetic polymorphisms in humans


14. Ah receptor gene polymorphisms and human cancer susceptibility


15. CYP1A1


16. Human cytochrome P4501A2


17. CYP2A subfamily: function, expression and genetic polymorphisms


18. Cytochrome P450 CYP2D6


19. Glutation-S-Transferases: influence of polymorphisms on cancer susceptibility


20. Polymorphic NAT's and cancer predisposition

21. Additional metabolic polymorphisms


22. Interaction between detoxifying enzyme polymorphisms and susceptibility to cancer


23. Review of studies of selected metabolic polymorphisms and cancer


Part 4. Prospects and implications


24. Genetics analysis of metabolic polymorphisms in molecular epidemiological studies; social and ethical implications


25. Conclusions and research perspectives

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