Metabolic polymorphisms and susceptibility to cancer /
Metabolic polymorphisms and susceptibility to cancer /
edited by Paolo Vineis ... [et al.].
- Lyon, France : Carey, NC : International Agency for Research on Cancer ; Distributed by Oxford University Press, 1999.
- xii, 510 p. : ill. ; 24 cm.
- IARC scientific publications, no. 148 0300-5085 ; .
Includes bibliographical references and index.
Part 1. General Aspects of the Study of Metabolic Polymorphisms
1. Why to study metabolic susceptibility to cancer
2. A nomenclature system for metabolic gene polymorphisms
3. Metabolism of xenobiotics and chemical carcinogenesis
4. Selection of candidate genes for popylation studies
5. Somatic alterations and metabolic polymorphisms
Part 2. Methodological Issues
6. Strategic issues in the design and interpretation of studies on metabolic polymorphisms and cancer susceptibility
7. Inherent difficulties in epidemiological studies involving phenotyping,
8. Xenobiotic-metabolizing enzymes and cancer risk: Correspondence between genotype and phenotype
9. The impact of misclassification in case-control studies of gene-environmental interaction
10. Epidemiological studies on genetics polymorphisms: Study design issues and measures of occurrence and associationa
11. Interaction, subgroup analysis, and sample size
12. Design and analysis issues in genetic case-control studies
Part 3. Role of Specific Enzymes in Cancer Susceptibility
13. Laboratory methods for the determination of genetic polymorphisms in humans
14. Ah receptor gene polymorphisms and human cancer susceptibility
15. CYP1A1
16. Human cytochrome P4501A2
17. CYP2A subfamily: function, expression and genetic polymorphisms
18. Cytochrome P450 CYP2D6
19. Glutation-S-Transferases: influence of polymorphisms on cancer susceptibility
20. Polymorphic NAT's and cancer predisposition
21. Additional metabolic polymorphisms
22. Interaction between detoxifying enzyme polymorphisms and susceptibility to cancer
23. Review of studies of selected metabolic polymorphisms and cancer
Part 4. Prospects and implications
24. Genetics analysis of metabolic polymorphisms in molecular epidemiological studies; social and ethical implications
25. Conclusions and research perspectives
9283221486
99485841
Cancer--Genetic aspects.
Cancer--Susceptibility.
Genetic polymorphisms.
RC268.4 / .M48 1999
QZ 200 M587 1999 / M587 1999
Includes bibliographical references and index.
Part 1. General Aspects of the Study of Metabolic Polymorphisms
1. Why to study metabolic susceptibility to cancer
2. A nomenclature system for metabolic gene polymorphisms
3. Metabolism of xenobiotics and chemical carcinogenesis
4. Selection of candidate genes for popylation studies
5. Somatic alterations and metabolic polymorphisms
Part 2. Methodological Issues
6. Strategic issues in the design and interpretation of studies on metabolic polymorphisms and cancer susceptibility
7. Inherent difficulties in epidemiological studies involving phenotyping,
8. Xenobiotic-metabolizing enzymes and cancer risk: Correspondence between genotype and phenotype
9. The impact of misclassification in case-control studies of gene-environmental interaction
10. Epidemiological studies on genetics polymorphisms: Study design issues and measures of occurrence and associationa
11. Interaction, subgroup analysis, and sample size
12. Design and analysis issues in genetic case-control studies
Part 3. Role of Specific Enzymes in Cancer Susceptibility
13. Laboratory methods for the determination of genetic polymorphisms in humans
14. Ah receptor gene polymorphisms and human cancer susceptibility
15. CYP1A1
16. Human cytochrome P4501A2
17. CYP2A subfamily: function, expression and genetic polymorphisms
18. Cytochrome P450 CYP2D6
19. Glutation-S-Transferases: influence of polymorphisms on cancer susceptibility
20. Polymorphic NAT's and cancer predisposition
21. Additional metabolic polymorphisms
22. Interaction between detoxifying enzyme polymorphisms and susceptibility to cancer
23. Review of studies of selected metabolic polymorphisms and cancer
Part 4. Prospects and implications
24. Genetics analysis of metabolic polymorphisms in molecular epidemiological studies; social and ethical implications
25. Conclusions and research perspectives
9283221486
99485841
Cancer--Genetic aspects.
Cancer--Susceptibility.
Genetic polymorphisms.
RC268.4 / .M48 1999
QZ 200 M587 1999 / M587 1999