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Molecular diversity and combinatorial chemistry : libraries and drug discovery / Irwin M. Chaiken, Kim D. Janda, [editors].

Contributor(s): Series: Conference proceedings series (American Chemical Society)Publication details: Washington, DC : American Chemical Society, c1996.Description: ix, 328 p. : ill. (some col.) ; 24 cmISBN:
  • 0841234507 (alk. paper)
  • 9780841234505
Subject(s): DDC classification:
  • QV 744 M718 1996
Online resources:
Contents:
Contents Strategies 1. Secondary Structure Templated Libraries: Mimicking Nature, M. Qabar, J. Urban, C. Sia, M. Klein, and M. Kahn 2. Construct Diversity: A New Paradigm for Combinatorial Chemistry, J.C. Roberts, B.E. Thomas, Y. Shen, A. Melikian-Badalian, P.J. Kowalczyk, and P.V. Pallai 3. Enhancing the Drug Discovery Process by Integration of High-Throughput Chemistry and Structure-Based Drug Design, T.L. Graybill, D.K. Agrafiotis, R. Bone, C.R. Illig, E.P. Jaeger, K.T. Locke, T. Lu, J.M. Salvino, R.M. Soll, J.C. Spulino, N. Subasinghe, B.E. Tomczuk, and F.R. Salemme 4. Phosphorus as a Scaffold: Combinatorial Libraries of Non-nucleotide Phosphoramidates, A.F. Cook and R. Fathi 5. Convergent Solid-Phase Synthesis of Phosphoramidate Combinatorial Libraries, N. Hebert 6. Solid-Phase Synthesis, Characterization, and Screening of a 43,000-Compound Tetrahydroisoquinoline Combinatorial Library, M.C. Griffith, C.T. Dooley, R.A. Houghten, and J.S. Kiely 7. Solid-Phase and Combinatorial Synthesis of Heterocyclic Scaffolds: Dihydropyridines, Pyridines, and Pyrido [2,3-d]pyrimidines, D.V. Patel, M. F. Gordeev, B.P. England, and E.M. Gordon 8. Polymer-Supported Chemistry: Synthesis of Small-Ring Heterocycles, A.M.M. Mjalli and B.E. Toyonaga 9. A Solution-Phase Strategy for the Parallel Synthesis of Chemical Libraries Containing Small Organic Molecules: A General Dipeptide Mimetic and a Flexible General Template, C.M. Tarby, S. Cheng, and D.L. Boger 10. Structurally Homogeneous and Heterogeneous Libraries: Scaffold-Based Libraries and Libraries Built Using Bifunctional Building Blocks, V. Krchnak, A. S. Weichsel, D. Cabel, and M. Lebl 11. Liquid-Phase Combinatorial Synthesis, D.J. Gravert and K.D. Janda 12. Libraries of Transition-Metal Catalysts: High-Throughput Screening of Catalysts for Synthetic Organic Methodology, K. Burgess, D. Moye-Sherman, and A.M. Porte 13. Mixtures of Molecules Versus Mixtures of Pure Compounds on Polymeric Beads, M. Stankova, P. Strop, C. Chen, and M. Lebl Biology-Based Chemical Libraries 14. Generation of Solution-Phase Libraries of Organic Molecules by Combinatorial Biocatalysis, Y.L. Khmelnitsky, P.C. Michels, J.S. Dordick, and D.S. Clark 15. Living Libraries Using Gene Transfer: A Renaissance for Natural Products, K.A. Thompson 16. Phage Expression of a De Novo Designed Coiled Coil Stem Loop Miniprotein Scaffold for Constrained Peptide Library Display, R.M. Miceli, D.G. Myszka, C. E. Peishoff, and I.M. Chaiken Automated Solid Phase Synthesis 17. Automation of High-Throughput Synthesis: Automated Laboratory Workstations Designed to Perform and Support Combinatorial Chemistry, J.R. Harness 18. Boosting the Productivity of Medicinal Chemistry Through Automation Tools: Novel Technological Developments Enable a Wide Range of Automated Synthetic Procedures, O. Gooding, P.D. Hoeprich, Jr., J.W. Labadie, J.A. Porco, Jr., P. van Eikeren, and P. Wright 19. A Modular System for Combinatorial and Automated Synthesis, S.H. DeWitt, B.R. Bear, J.S. Brussolo, M.J. Duffield, E.M. Hogan, C.E. Kibbey, A.A. MacDonald, D.G. Nickell, R.L. Rhoton, and G.A. Robertson 20. LiBrain: Software for Automated Design of Exploratory and Targeted Combinatorial Libraries, A. Polinsky, R.D. Feinstein, S. Shi, and A. Kuki 21. Automation Issues at the Interface Between Combinatorial Chemistry and High-Throughput Screening, B.E. Bauer Analytical Methods and Screening 22. Tools for Combinatorial Chemistry, K. Russell, D.C. Cole, F.M. McLaren, and D.E. Pivonka 23. Magic-Angle Spinning NMR Spectroscopy of Polystyrene-Bound Organic Molecules: Monitoring a Three-Step Solid-Phase Synthesis Involving a Heck Reaction, C. Dhalluin, I. Pop, B. Deprez, P. Melnyk , A. Tartar, and G. Lippens 24. A High-Throughput Functional Assay for G-Protein-Coupled Receptors: Method for Screening Combinatorial Libraries, C. J. Molineaux, W. Goodwin, L. Chai, X. Zhang, and D. I. Israel Application 25. Use of Combinatorial Libraries in the Discovery and Development of Novel Anti-infectives, M. A. Wuonola and D.G. Powers 26. Application of Polymer-Supported Chemistry to the Discovery and Optimization of Lead Drug Candidates, A.L. Harris and B.E. Toyonaga 27. Using Pharmacophore Diversity To Select Molecules To Test from Commercial Catalogues, K. Davies
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Holdings
Item type Current library Call number Copy number Status Date due Barcode
Book Open Access Book Open Access Health Sciences Library QV 744 M718 1996 (Browse shelf(Opens below)) 1 Available MBAL22010871

Includes bibliographical references and indexes.

Contents
Strategies
1. Secondary Structure Templated Libraries: Mimicking Nature, M. Qabar, J. Urban, C. Sia, M. Klein, and M. Kahn
2. Construct Diversity: A New Paradigm for Combinatorial Chemistry, J.C. Roberts, B.E. Thomas, Y. Shen, A. Melikian-Badalian, P.J. Kowalczyk, and P.V. Pallai
3. Enhancing the Drug Discovery Process by Integration of High-Throughput Chemistry and Structure-Based Drug Design, T.L. Graybill, D.K. Agrafiotis, R. Bone, C.R. Illig, E.P. Jaeger, K.T. Locke, T. Lu, J.M. Salvino, R.M. Soll, J.C. Spulino, N. Subasinghe, B.E. Tomczuk, and F.R. Salemme
4. Phosphorus as a Scaffold: Combinatorial Libraries of Non-nucleotide Phosphoramidates, A.F. Cook and R. Fathi
5. Convergent Solid-Phase Synthesis of Phosphoramidate Combinatorial Libraries, N. Hebert
6. Solid-Phase Synthesis, Characterization, and Screening of a 43,000-Compound Tetrahydroisoquinoline Combinatorial Library, M.C. Griffith, C.T. Dooley, R.A. Houghten, and J.S. Kiely
7. Solid-Phase and Combinatorial Synthesis of Heterocyclic Scaffolds: Dihydropyridines, Pyridines, and Pyrido [2,3-d]pyrimidines, D.V. Patel, M. F. Gordeev, B.P. England, and E.M. Gordon
8. Polymer-Supported Chemistry: Synthesis of Small-Ring Heterocycles, A.M.M. Mjalli and B.E. Toyonaga
9. A Solution-Phase Strategy for the Parallel Synthesis of Chemical Libraries Containing Small Organic Molecules: A General Dipeptide Mimetic and a Flexible General Template, C.M. Tarby, S. Cheng, and D.L. Boger
10. Structurally Homogeneous and Heterogeneous Libraries: Scaffold-Based Libraries and Libraries Built Using Bifunctional Building Blocks, V. Krchnak, A. S. Weichsel, D. Cabel, and M. Lebl
11. Liquid-Phase Combinatorial Synthesis, D.J. Gravert and K.D. Janda
12. Libraries of Transition-Metal Catalysts: High-Throughput Screening of Catalysts for Synthetic Organic Methodology, K. Burgess, D. Moye-Sherman, and A.M. Porte
13. Mixtures of Molecules Versus Mixtures of Pure Compounds on Polymeric Beads, M. Stankova, P. Strop, C. Chen, and M. Lebl
Biology-Based Chemical Libraries
14. Generation of Solution-Phase Libraries of Organic Molecules by Combinatorial Biocatalysis, Y.L. Khmelnitsky, P.C. Michels, J.S. Dordick, and D.S. Clark
15. Living Libraries Using Gene Transfer: A Renaissance for Natural Products, K.A. Thompson
16. Phage Expression of a De Novo Designed Coiled Coil Stem Loop Miniprotein Scaffold for Constrained Peptide Library Display, R.M. Miceli, D.G. Myszka, C. E. Peishoff, and I.M. Chaiken

Automated Solid Phase Synthesis

17. Automation of High-Throughput Synthesis: Automated Laboratory Workstations Designed to Perform and Support Combinatorial Chemistry, J.R. Harness
18. Boosting the Productivity of Medicinal Chemistry Through Automation Tools: Novel Technological Developments Enable a Wide Range of Automated Synthetic Procedures, O. Gooding, P.D. Hoeprich, Jr., J.W. Labadie, J.A. Porco, Jr., P. van Eikeren, and P. Wright
19. A Modular System for Combinatorial and Automated Synthesis, S.H. DeWitt, B.R. Bear, J.S. Brussolo, M.J. Duffield, E.M. Hogan, C.E. Kibbey, A.A. MacDonald, D.G. Nickell, R.L. Rhoton, and G.A. Robertson
20. LiBrain: Software for Automated Design of Exploratory and Targeted Combinatorial Libraries, A. Polinsky, R.D. Feinstein, S. Shi, and A. Kuki
21. Automation Issues at the Interface Between Combinatorial Chemistry and High-Throughput Screening, B.E. Bauer

Analytical Methods and Screening
22. Tools for Combinatorial Chemistry, K. Russell, D.C. Cole, F.M. McLaren, and D.E. Pivonka
23. Magic-Angle Spinning NMR Spectroscopy of Polystyrene-Bound Organic Molecules: Monitoring a Three-Step Solid-Phase Synthesis Involving a Heck Reaction, C. Dhalluin, I. Pop, B. Deprez, P. Melnyk , A. Tartar, and G. Lippens
24. A High-Throughput Functional Assay for G-Protein-Coupled Receptors: Method for Screening Combinatorial Libraries, C. J. Molineaux, W. Goodwin, L. Chai, X. Zhang, and D. I. Israel



Application
25. Use of Combinatorial Libraries in the Discovery and Development of Novel Anti-infectives, M. A. Wuonola and D.G. Powers
26. Application of Polymer-Supported Chemistry to the Discovery and Optimization of Lead Drug Candidates, A.L. Harris and B.E. Toyonaga
27. Using Pharmacophore Diversity To Select Molecules To Test from Commercial Catalogues, K. Davies

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