Molecular diversity and combinatorial chemistry Libraries and drug discovery/ edited by Irwin M. Chaiken and Kim D. Janda

pt. 1. Strategies
Secondary structure templated libraries: mimicking nature / Maher Qabar
Construct diversity: a new paradigm for combinatorial chemistry / John C. Roberts
Enhancing the drug discovery process by integration of high-throughput chemistry and structure-based drug design / T.L. Graybill
pt. 2. Library design: solid-, solution-, and liquid-phase combinatorial synthesis
Phosphorus as a scaffold: combinatorial libraries of non-nucleotide phosphoramidates / Alan F. Cook
Convergent solid-phase synthesis of phosphoramidate combinatorial libraries / Normand Hébert
Solid-phase synthesis, characterization, and screening of a 43,000-compound tetrahydroisoquinoline combinatorial library / Michael C. Griffith
Solid-phase and combinatorial synthesis of heterocyclic scaffolds: dihydropyridines, pyridines, and pyrido[2,3-d]pyrimidines / Dinesh V. Patel
Polymer-supported chemistry: synthesis of small-ring heterocycles / A.M.M. Mjalli
A solution-phase strategy for the parallel synthesis of chemical libraries containing small organic molecules: a general dipeptide mimetic and a flexible general template / Christine M. Tarby
Structurally homogeneous and heterogeneous libraries: scaffold-based libraries and libraries built using bifunctional building blocks / Viktor Krchňák
Liquid-phase combinatorial synthesis / Dennis J. Gravert
Libraries of transition-metal catalysts: high throughput screening of catalysts for synthetic organic methodology / Kevin Burgess
Mixtures of molecules versus mixtures of pure compounds on polymeric beads / Magda Stankova
pt. 3. Biology-based chemical libraries
Generation of solution-phase libraries of organic molecules by combinatorial biocatalysis / Yuri L. Khmelnitsky
Living libraries using gene transfer: a renaissance for natural products / K.A. Thompson
Phage expression of a de novo designed coiled coil stem loop miniprotein scaffold for constrained peptide library display / Robert M. Miceli
pt. 4. Automated solid-phase synthesis
Automation of high-throughput synthesis: automated laboratory workstations designed to perform and support combinatorial chemistry / James R. Harness
Boosting the productivity of medicinal chemistry through automation tools: novel technological developments enable a wide reange of automated synthetic procedures / Owen Gooding
A modular system for combinatorial and automated synthesis / S.H. DeWitt
LiBrain: software for automated design of exploratory and targeted combinatorial libraries / A. Polinsky
Automation issues at the interface between combinatorial chemistry and high-throughput screening / Barr E. Bauer
pt. 5. Analytical methods and screening
Tools for combinatorial chemistry / Keith Russell
Magic-angle spinning NMR spectroscopy of polystyrene-bound organic molecules: monitoring a three-step solid-phase synthesis involving a heck reaction / Christophe Dhalliun
A high-throughput functional assay for G-protein-coupled receptors: method for screening combinatorial libraries / Christopher J. Molineaux
pt. 6. Applications
Use of combinatorial libraries in the discovery and development of novel anti-infectives / Mark A. Wuonola
Application of polymer-supported chemistry to the discovery and optimization of lead drug candidates / A.L. Harris
Using pharmacophore diversity to select molecules to test from commercial catalogues / Keith Davies

Index included