The Maillard reaction : chemistry at the interface of nutrition, aging, and disease / edited by John W. Baynes ... [et al.].

Includes bibliographical references and index.

CONTENTS

Preface. By John W Baynes, Suzanne R. Thorpe, Jennifer M. Ames, and Vincent M. Monnier
Dedication: Dr. Paul-Andre Finot and Dr. Samuel Rahbar. By Vincent Monnier
Keynote Papers
Historical Perspective of the Maillard Reaction in Food Science. By Paul-Andre Finot
The Discovery of Glycated Hemoglobin: A Major Event in the Study of Nonenzymatic Chemistry in Biological Systems. By Samuel Rahbar

Part I. Chemistry of the Maillard Reaction
Taste-Active Maillard Reaction Products: The "Tasty" World of Nonvolatile Maillard Reaction Products. By Thomas Hofmann
Current Status of Acrylamide Research in Food: Measurement, Safety Assessment, and Formation. By Imre Blank
Oxidative Pyrolysis and Postpyrolytic Derivatization Techniques for the Total Analysis of Maillard Model Systems: Investigation of Control Parameters of Maillard Reaction Pathways. By V.A. Yaylayan, L. Haffenden, F.L. chu, and A. Wnorowski
Identification of N7-(1-Carboxyethyl)-Arginine, a Novel Posttranslational Protein Modification of Arginine Formed at High Hydrostatic Pressure. By Nadia Alt and Peter Schieberle
Labeling Studies on the Formation Pathway of N[epsilon]-Carboxymethyllysine in Maillard-type Reactions. By Martina Kasper and Peter Schieberle
Elucidation of Chemical Pathways in the Maillard Reaction by 17O-NMR Spectroscopy. By Fabien Robert, Francia Arce Vera, Frank Kervella, Tomas Davidek, and Imre Blank
The Origin and Yield of Acetic Acid: The Effect of Reaction Conditions on the Origin and Yields of Acetic Acid Generated by the Maillard Reaction. By Tomas Davidek, Stephanie Devaud, Fabien Robert, and Imre Blank
Formation of Mutagenic/Carcinogenic Heterocyclic Amines under Moderate Conditions. By Naohide Kinae, Chisato Mori, Kaori Kujirai, Shoji Masumori, and Shuichi Masuda
Maillard Reactions of Ribose 5-Phosphate and Amino Acids. By Roger Sandwick, Matthew Johanson, and Elizabeth Breuer
Protein Cross-Linking in Food. By J.A. Gerrard, S.J. Meade, A.G. Miller, P.K. Brown, S.B.M. Yasir, K.H. Sutton, and M.P. Newberry
Chemistry and Biological Effects of Melanoidins and GLAP as Advanced Glycation End Products. By Fumitaka Hayase, Teruyuki Usui, Kazuyuki Nishiyama, Shigeyuki Sasaki, Yoshinobu Shirahashi, Naoyuki Tsuchiya, Naoko Numata, and Hirohito Watanabe

Part II. Reactive Carbonyls and the Maillard Reaction in Biological Systems
Dicarbonyl Intermediates in the Maillard Reaction. By Paul J. Thornalley
Ornithine Is a Novel Amino Acid and a Marker of Arginine Damage by Oxoaldehydes in Senescent Proteins. By David R. Sell and Vincent M. Monnier
Formation of alpha-Animoadipic and gamma-Glutamic Semialdehydes in Proteins by the Maillard Reaction. By Mitsugu Akagawa, Daisuke Sasaki, Yayoi Kurota, and Kyozo Suyama
Methylglyoxal Can Modify GAPDH Activity and Structure. By Hyon Jae Lee, Scott. K. Howell, Rebecca J. Sanford, and Paul J. Beisswenger
Effect of Glucose Concentration on Formation of Advanced Glycation End Products in Erythrocytes in Vivo. By Ryoji Nagai, Elizabeth K. Deemer, Jonathan W. Brock, Suzanne R. Thorpe, and John W. Baynes
Methylglyoxal Induces Apoptosis through Oxidative Stress-Mediated Activation of p38 Mitogen-Activated Protein Kinase in Rat Schwann Cells. By Michiru Fukunaga, Satoshi Miyata, Satomi Higo, Yasuhiro Hamada, Shigemitsu Ueyama, and Masato Kasuga
Dicarbonyl Stress and Apoptosis of Vascular Cells: Prevention by AlphaB-Crystallin. By Ram H. Nagaraj, Tomoko Oya-Ito, Manjunatha Bhat, and Bingfen Liu
Phototransformations of Advanced Glycation End Products in the Human Eye Lens due to Ultraviolet A Light Irradiation. By G.K. Argirov, B. Lin, and B.J. Ortwerth
The Maillard Reaction for Sunlight Protection. By Ramon M. Fusaro and Edwin G. Rice
K2P--a Novel Cross-Link from Human Lens Protein. By Rongzhu Cheng, Qi Feng, Ognyan K. Argirov, and Beryl J. Ortwerth
Assessment of Protein Function following Cross-Linking by alpha-Dicarbonyls. By Antonia G. Miller and Juliet A. Gerrard
Ketosis Leads to Increased Methylglyoxal Production on the Atkins Diet. By Benjamin G.K. Beisswenger, Elizabeth M. Delucia, Nancy Lapoint, Rebecca J. Sanford, and Paul J. Beisswenger
Methylglyoxal, Glyoxal, and Their Detoxification in Alzheimer's Disease. By Bjorn Kuhla, Hans-Joachim Luth, Dietrich Haferburg, Katharina Boeck, Thomas Arendt, and Gerald Munch
Evaluation of Glyoxal and Methylglyoxal Levels in Uremic Patients under Peritoneal Dialysis. A. Lapolla, R. Flamini, A. Lupo, N.C. Aroico, C. Rugiu, R. Reitano, M. Tubaro, E. Ragazzi, R. Seraglia, and P. Traldi

Part III. Analytical Methods for Measuring Maillard Reaction Products
Application of Semiquantitative Proteomics Techniques to the Maillard Reaction. By Jennifer M. Ames
The Carbon Module Labeling (CAMOLA) Technique: A Useful Tool for Identifying Transient Intermediates in the Formation of Maillard-Type Target Modules. By Peter Schieberle
Analysis of Protein Glycation Products by MALDI-TOF/MS. By Thomas Kislinger, Andreas Humeny, Carlo C. Peich, Cord-Michael Becker, and Monika Pischetsrieder
Peptide Mapping of Human Serum Albumin Modified Minimally by Methylglyoxal in Vitro and in Vivo. by Naila Ahmed and Paul J. Thornalley
Advanced Glycation End Products/Peptides: An in Vivo Investigation. By A. Lapolla, D. Fedele, R. Reitano, L. Bonfante, G. Pastori, R. Seraglia, M. Tubaro, and P. Traldi
Convenient Method for Preparation of High-Purity, Amadori-Glycated Phosphatidylethanolamine and Its Prooxidant Effect. By Teruo Miyazawa, Jeong-Ho Oak, and Kiyotaka Nakagawa
Tandem Mass Spectrometry Analysis of Amadori-Glycated Phosphatidylethanolamine in Human Plasma. By Teruo Miyazawa, Jeong-Ho Oak, and Kiyotaka Nakagawa
Proteomic Method for the Quantification of Methionine Sulfoxide. By J.W.C. Brock, W.C. Cotham, J.M. Ames, S.R. Thorpe, and J.W. Baynes
Simple Noninvasive Measurement of Skin Autofluorescence. By Robbert Meerwaldt, Thera Links, Reindert Graaff, Susan Thorpe, John Baynes, Jasper Hartog, Reinold Gans, and Andries Smit
Accumulation of Advanced Glycation End Products, Measured as Skin Autofluorescence, in Renal Disease. By Jasper W.L. Hartog, Aiko P.J. de Vries, Helen L. Lutgers, Robbert Meerwaldt, Roel M. Huisman, Willem J. van Son, Paul E. de Jong, and Andries J. Smit
Evaluation of the Maillard Reaction in Infant Formulas by Means of Front-Face Fluorescence. By I. Birlouez-Aragon, N. Locquet, E. de St. Louvent, D. Jouan-Rimbaud Bouveresse, and P. Stahl

Part IV. Lipids and Lipoproteins in Nutrition and Disease
Interplay between the Maillard Reaction and Lipid Peroxidation in Biochemical Systems. By Francisco J. Hidalgo and Rosario Zamora
Isolevuglandins, Oxidatively Truncated Phospholipids, and Atherosclerosis. By Robert G. Salomon
Role of Glucoxidation and Lipid Oxidation in the Development of Atherosclerosis. By Erwin Schleicher, Cora Weigert, Helmut Rohrbach, Andreas Nerlich, Beatrice Bachmeier, and Ulrich H. Friess
Is Atherosclerosis a Multifactorial Disease or Is It Inducted by a Sequence of Oipid Peroxidation Reactions? By Gerhard Spiteller
The Immunogenicity of Modified Lipoproteins. By Maria F. Lopes-Virella, Suzanne R. Thorpe, M. Brooks Derrick, Charlyne Chassereau, and Gabriel Virella
Glycation Does Not Alter LDL-Induced Secretion of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 from Human Aortic Endothelial Cells. By Richard L. Klein, Andrea J. Semler, John W. Baynes, Suzanne R. Thorpe, Timothy J. Lyons, and Alicia J. Jenkins
Effects of Modified LDL on Human Retinal Pericyte Survival. By Weiwei Song, Jeremy L. Barth, Kangmo Lu, Yongxin Yu, Yan Huang, Cynthia K. Gittinger, W. Scott Argraves, and Timothy J. Lyons.
Acrolein Modifies Apolipoprotein A-I in the Human Artery Wall. By Baohai Shao, Kevin D. O'Brien, Thomas O. McDonald, Xiaoyun Fu, John F. Oram, Koji Uchida, and Jay W. Heinecke
Lipid-Derived Modifications of Plasma Proteins in Experimental and Human Diabetes. By Andrzej S. Januszewski, Alicia J. Jenkins, John W. Baynes, and Suzanne R. Thorpe
Angiogenic Potency of Amadori-Glycated Phosphatidylethanolamine. By Kiyotaka Nakagawa, Jeong-Ho Oak, and Teruo Miyazawa
Covalent Binding of Acetone to Aminophospholipids in Vitro and in Vivo. By Arnis Kuksis, Amir Ravandi, and Michael Schneider

Part V. Oxidative Stress, Diet, and Aging
Protective Role of Antioxidative Food Factors in Oxidative Stress Caused by Hyperglycemia. By Toshihiko Osawa and Yoji Kato
Advanced Glycation in Health and Disease: Role of the Modern Environment. By Helen Vlassara
Diet-Derived Advanced Glycation End Products Are Major Contributors to the Body's AGE Pool and Induce Inflammation in Healthy Subjects. By Jaime Uribarri, Weijing Cai, Oana Sandu, Melpomeni Peppa, Teresia Goldberg, and Helen Vlassara
Are Food Advanced Glycation End Products Toxic in Biological Systems? By N.V. Chuyen, H. Arai, T. Nakanishi, and N. Utsunomiya
Studies on Absorption and Elimination of Dietary Maillard Reaction Products. By Anke Forster, Yvonne Kuhne, and Thomas Henle
Renal Effects of Oral Maillard Reaction Product Load in the Form of Bread Crusts in Healthy and Subtotally Nephrectomized Rats. By Katarina Sebekova, Thomas Hofmann, Peter Boor, Katarina Sebekova, Jr., Ol'ga Ulicna, Helmut F. Erbersdobler, John W. Baynes, Suzanne R. Thorpe, August Heidland, and Veronika Somoza
Dietary Bread Crust Advanced Glycation End Products Bind to the Receptor for AGEs in HEK-293 Kidney Cells but Are Rapidly Excreted after Oral Administration to Healthy and Subtotally Nephrectomized Rats. By Veronika Somoza, Michael Lindenmeier, Thomas Hofmann, Oliver Frank, Helmut F. Erbersdobler, John W. Banes, Suzanne R. Thorpe, August Heidland, and Katarina Sebekova
Biological and Chemical Assessment of Antioxidant Activity of Sugar-Lysine Model Maillard Reaction Products. By David D. Kitts and Chun Hu
Prevention of Oxidative Stress by Adenoviral Overespression of Glutathione-Related Enzymes in Pancreatic Islets. By R. Paul Robertson, Yoshito Tanaka, Hiroki Takahashi, Phuong Oanh T. Tran, and Jamie S. Harmon
A Common Pathway for Intracellular Reactive Oxygen Species Production by Glycoxidative and Nitroxidative Stress in Vascular Endothelial Cells and Smooth Muscle Cells. By Naoyuki Taniguchi, Motoko Takahashi, Haruhiko Sakiyama, Yong Seek Park, Michio Asahi, Yoshiko Misonou, and Yasuhade Miyamoto
An in Vitro Approach to the Chronological Aging of Skin by Glycation of the Collagen: The Biological Effect of Glycation on the Reconstructed Skin Model. By Herve Pageon and Daniel Asselineau
Cross-Linking of the Extracellular Matrix by the Maillard Reaction in Aging and Diabetes: An Update on a Puzzle Approaching Resolution. By Vincent M. Monnier, Georgian T. Mustata, Klaus L. Biemel, Oliver Reihl, Marcus O. Lederer, Dai Zhenyu, and David R. Sell
Oxidative Stress and Neurodegeneration. By Paula I. Moreira, Mark A. Smith, Xiongwei Zhu, Akihiko Nunomura, Rudy J. Castellani, and George Perry

Part VI. Role of Advanced Glycation End Products in Diabetes
Receptor of Advanced Glycation End Products and Its Ligands: A Journey from the Complications of Diabetes to Its Pathogenesis. By William Kim, Barry I. Hudson, Bernhard Moser, Jiancheng Guo, Ling Ling Rong, Yan Lu, Wu Qu, Evanthia Lalla, Shulamit Lerner, Yali Chen, Chirley Shi Du Yan, Vivette D'Agati, Yoshifumi Naka, Ravichandran Ramasamy, Kevan Herold, Shi Fang Yan, and Ann Marie Schmidt
Receptor for Advanced Glycation End Products Is a Promising Target of Diabetic Nephropathy. By Yasuhiko Yamamoto, Toshio Doi, Ichiro Kato, Harumichi Shinohara, Shigeru Sakurai, Hideto Yonekura, Takuo Watanabe, Kihn Mar Myint, Ai Harashima, Masayoshi Takeuchi, Shin Takasawa, Hiroxhi Okamoto, Noriyoshi Hashimoto, Masahide Asano, and Hiroshi Yamamoto
Glycation Products as Markers and Predictors of the Progression of Diabetic Complications. By Vincent M. Monnier, David R. Sell, and Saul Genuth
The Maillard Reaction in Eye Diseases. By Alan W. Stitt
Role of Advanced Glycation End Products and Their Receptors in Development of Diabetic Neuropathy. By Ryuichi Wada and Soroku Yagihashi
Synergistic Contributions of Carbonyl Stress and Megsin: Central Players in Diabetic Nephropathy. By Reiko Inagi, Masaomi Nangaku, and Toshio Miyata
Effects of Advanced Glycation End Products on Ezrin-Dependent Functions in LLC-PK1 Proximal Tubule Cells. By Leon A. Bach, Mariso A. Gallicchio, E. Anne McRobert, Anjali Tikoo, and Mark E. Cooper
Localization of the Ezrin Binding Epitope for Glycated Proteins. By E. Anne McRobert, Anjali Tikoo, Marisa A. Gallicchio, Mark E. Cooper, and Leon A. Bach
Processing Advanced Glycation End Product-Modified Albumin by the Renal Proximal Tubule and the Early Pathogenesis of Diabetic Nephropathy. By Aylin M. Ozdemir, Ulrich Hopfer, Penny Erhard, Vincent M. Monnier, and Miriam F. Weiss
Significance of Proximal Tubular Metabolism of Advanced Glycation End Products in Kidney Diseases. By Akihiko Saito, Tetsuro Takeda, Kiyoko Sato, Hitomi Hama, Atsuhito Tanuma, Ryohei Kaseda, Yoshiki Suzuki, and Fumitake Gejyo
Low-Molecular-Weight Advanced Glycation End Products: Markers of Tissue AGE Accumulation and More? Merlin C. Thomas, Josephine M. Forbes, Richard MacIssaac, George Jerums, and Mark E. Cooper
Plasma Low-Molecular-Weight Fluorescence in Type 1 Diabetes Mellitus. By A.S. Januszewski, M.C. Thomas, S.J. Chung, C.S. Karschimkus, K.G. Rowley, C. Nelson, D. O'Neal, Z. Wang, J.D. Best, and A.J. Jenkins
Plasma Levels of AGE Peptides in Type 1 Diabetic Patients Are Associated with Serum Creatinine and Not with Albumin Excretion Rate: Possible Role of AGE Peptide-Associated Endothelial Dysfunction. By Casper G. Schalkwijk, Piet M. ter Wee, and Coen D.A. Stehouwer

Part VII. Role of Advanced Glycation End Products in Organ Dysfunction and Disease
Pathological Roles of Advanced Glycation End Product Receptors SR-A and CD36. By Seikoh Horiuchi, Yuka Unno, Hitomi Usui, Kenichi Shikata, Kaori Takaki, Wakako Koito, Yu-Ichiro Sakamoto, Ryoji Nagai, Kenji Makino, Akira Sasao, Jun Wada, and Hirofumi Makino
Advanced Glycation End Product Receptor-Mediated Cellular Dysfunction. By Angelika Bierhaus, Per M. Humpert, David M. Stern, Bernd Arnold, and Peter P. Nawroth
Advanced Glycation End Products: A Possible Link to Angiotensin in an Animal Model. By Jurgen Bohlender, Sybille Franke, Manfred Sommer, and Gunter Stein
Genotoxicity of Advanced Glycation End Products. By Nicole Schupp, Reinhard Schinzel, August Heidland, and Helga Stopper
Glycoaldehyde-Modified Bovine Serum Albumin Downregulates Leptin Expression in Mouse Adipocytes via a CD36-Mediated Pathway. Yuka Unno, Masakazu Sakai, Yu-Ichiro Sakamoto, Akihiko Kuniyasu, Ryoji Nagai, Hitoshi Nakayama, and Seikoh Horiuchi
Aldose Reductase and AGE-RAGE Pathways: Key Players in Myocardial Ischemic Injury. By Michiyo Kaneko, Loredana Bucciarelli, Yuying C. Hwang, Larisee Lee, Shi Fang Yan, Ann Marie Schmidt, and Ravichandran Ramasamy
Advanced Glycation End Products and Bone Loss during Aging. By Patrizio Odetti, Simona Rossi, Fiammetta Monacelli, Alessia Poggi, Maria Cirnigliaro, Marcello Federici, and Alberto Federici
Increased Protein Glycation in Cirrhosis and Therapeutic Strategies to Prevent It. By Naila Ahmed, Reinhard Luthen, Dieter Haussinger, Katarina Sebekova, Reinhard Schinzel, Wolfram Voelker, August Heidland, and Paul J. Thornalley
Advanced Glycation End Products in Human Cancer Tissues: Detection of N-epsilon-(Carboxymethyl)lysine and Argpyrimidine. By Jeroen W.J. van Heijst, Hans W.M. Niessen, Klaas Hoekman, and Casper G. Schalkwijk
Advanced Glycation End Product-Free Adducts Are Cleared by Dialysis. S. Agalou, N. Ahmed, P.J. Thornalley, and A. Dawnay

Part VIII. Inhibitors of the Maillard Reaction
From Molecular Footprints of Disease to New Therapeutic Interventions in Diabetic Nephropathy. By Toshio Miyata, Naoyoshi Ishikawa, Makoto Yamamoto, Hiroshi Onogi, and Yuko Izuhara
Can Advanced Glycation End Product Inhibitors Modulate More Than One Pathway to Enhance Renoprotection in Diabetes? By Melinda T. Coughlan, Mark E. Cooper, and Josephine M. Forbes
Advanced Glycation End Products in Diabetes-Associated Atherosclerosis and Renal Disease: Interventional Studies. By Karin A. Jandeleit-Dahm, Markus Lassila, and Terri J. Allen
Renoprotective and Lipid-Lowering Effects of LR Compounds, Novel Advanced Glycation End Product Inhibitors, in Streptozotocin-Induced Diabetic Rats. By James Lester Figarola, Steven Scott, Sofia Loera, Bixin Xi, Timothy Synold, and Samuel Rahbar
High-Dose Thiamine Therapy Counters Dyslipidemia and Advanced Glycation of Plasma Protein in Streptozotocin-Induced Diabetic Rats. By Nikolaos Karachalias, Roya Babaei-Jadidi, Christian Kupich, Naila Ahmed, and Paul J. Thornalley
Inhibitors of Advanced Glycation End Product Formation and Neurovascular Dysfunction in Experimental Diabetes. By Norman E. Cameron, T. Michael Gibson, Matthew R. Nangle, and Mary A. Cotter
Post-Amadori AGE Inhibition as a Therapeutic Target for Diabetic Complications: A Rational Approach to Second-Generation Amadorin Design. By Raja G. Khalifah, Ying Chen, and James J. Wassenberg
Pyridoxamine: The Many Virtues of a Maillard Reaction Inhibitor. By Paul A. Voziyan and Billy G. Hudson
Tissue-Specific Variation in Glycation of Proteins in Diabetes: Evidence for a Functional Role of Amadoriase Enzymes. By Sarah M. Brown, Della M. Smith, Nadia Alt, Suzanne R. Thorpe, and John W. Baynes
Some Clues as to the Regulation, Expression, Function, and Distribution of Fructosamine-3-Kinase and Fructosamine-3-Kinase-Related Protein. By James R. Conner, Paul J. Beisswenger, and Benjamin S. Szwergold
Substrate Specificity of Amadoriase I from Aspergillus fumigatus. By Carmela Mennella, Rosa Cinzia Borrelli, Francesco Vinale, Michelina Ruocco, and Vincenzo Fogliano
Transglycation--A Potential New Mechanism for Deglycation of Schiff's Bases. By Benjamin S. Szwergold, Scott K. Howell, and Paul J. Beisswenger
Proteins of Thermus thermophilus Are Resistant to Glycation-Induced Protein Precipitation: An Evolutionary Adaptation to Life at Extreme Temperatures? By Gerald Munch, Katrin Berbaum, Christin Urban, and Reinhard Schinzel
Maillard Reaction Products Derived from Thiol Compounds as Inhibitors of Enzymatic Browning of Fruits and Vegetables: The Structure-Activity Relationship. By C. Billaud, C. Maraschin, M.-N. Peyrat-Maillard, and J. Nicolas

Part IX. Poster Abstracts
The Life and Works of L. C. Maillard: Some Interesting Aspects of His Biography. By Paul A. Finot and J. Adrian
Pronyl-Lysine--A Novel Protein Modification in Bread Crust Melanoidins Showing in Vitro Antioxidative and Phase I/II-Enzyme Modulating Activity. By T. Hofmann, M. Lindenmeier, and V. Somoza
Can Histidines Stabilize a Carnosine-Derived Pyrazinium Radical? By N.W. Seidler and G.S. Yeargans
The Interaction of Heavy Metals (Cu, Fe, and Zn) with Maillard Reaction Products in the Lactose-Glycine System. By D.T. Ramonaityte, M. Kersiene, and B. Mockaitiene
Modeling the Maillard Reaction: Schiff Base Formation. Lai Peng Leong and Ryan P.A. Bettens
Creating Caseinate Glycoconjugtates with Novel Functionality through the Maillard Reaction. By C. Oliver, L. Melton, and R. Stanley
A Rapid Fluorimetric Method to Predict the Browning and HMF Content of Biscuits. By L. Ait Ameur, C. Chipeaux, M. Zude, G. Trystram, and I. Birlouez-Aragon
Influence of High Hydrostatic Pressure on the Formation of Maillard-Derived Key Odorants and Chromophores. By T. Hofmann, F. Deters, I. Heberle, and P. Schieberle
The Effect of Water Content on Volatile Formation from the Maillard Reaction of Peptides and Glucose. By C.Y. Lu, R. Payne, and C.T. Ho
The Roles of Free and Bound Amino Acids in Maillard Aroma Generation. By C.T. Ho, C.Y. Lu, C.P. Liang, and M. Wang
Volatile Components in Pork Semimembranosus Pan-Fried at Two Pan Temperatures. By M.D. Aaslyng, A. Schafer, and L. Andersen
Degradation of Amadori Compounds by Flavin Adenine Dinucleotide. By H.A. Watanabe, T.A. Nagatake, M.A. Naiki, M.A. Hashimoto, K.A. Ito, and F.B. Hayase
Neurotoxic Tetrahydroisoquinoline Derivatives Formed by the Maillard Reaction between Glucose and Dopamine. By Kyozo Suyama, Yoshihisa Ishii, and Mitsugu Akagawa
Isolation and Identification of Glyceraldehyde-Derived Advanced Glycation End Products. By T. Usui, K. Shimohira, H. Watanabe, and F. Hayase
Antioxidant Properties of Proline-Glucose-Ferulic Acid Model Malt Systems. By Thomas S. Samaras, Michel M. Gordon, and Jennifer M. Ames
The Effect of Oxidation on the Antioxidant Activity of Phospholipids. By F.J. Hidalgo, F. Nogales, and R. Zamora
PA49.5, the Principal Asset of Lactococcus lactis Sp. cremoris ATCC 9596. By E. Dako, A. Asselin, and E.R. Simard
Specific MS/MS Fragmentation of Lysine, Arginine, and Ornithine Glycation Products Provides an Opportunity for Their Selective Detection in Protein Acid Hydrolysates and Enzymatic Digests. By O.K. Argirov, N.D. Leigh, and B.J. Ortwerth
Site Specificity of Glycation and N[epsilon]-(Carboxymethyl)Lysine Formation on Bovine Serum Albumin Modified by Glucose and Fructose. By D.J.S. Hinton and J.M. Ames
Peptide Mapping of Human Hemoglobin Modified Minimally by Methylglyoxal in Vitro. By Y. Chen, N. Ahmed, and P.J. Thornalley
Peptide Mapping of Type IV Collagen Modified Minimally by Methylglyoxal in Vitro. By Darin Dobler, Naila Ahmed, and Paul J. Thornalley
Protein Glycation and Oxidation in Cola and Pasteurized Milk. By L. Kennish, D. Dobler, N. Ahmed, and P.J. Thornalley
Biological Response of Advanced Glycation End Products to the Established Cell Line and Proteome Analysis. By S. Omura, A. Taya, S. Masuda, H. Naitou, N. Ohashi, and N. Kinae
Proteomic Analysis of the Secreted Proteins of the B3 Line of Transformed Human Lens Epithelial (HLE-B3) Cells That Were Exposed to the Cytotoxicity of the Oxidation-Derived Aldehyde. By Hiroko Odani, Toyofumi Nakanishi, and Vincent M. Monnier
Quantification of Advanced Glycation End Product and Oxidative Stress Biomarkers in Human Urine. By Yoji Katok, Nobuhiko Mizukawa, Jun-Ichi Yano, Tomoyoshi Hosokawa, Akihiro Yoshido, Michitaka Naito, Yoshichika Kawai, Kentaro Tsuji, Noritoshi Kitamoto, Masayasu Kitamura, and Toshihiko Osawa
Skin Autofluorescence, a Noninvasive Measure of Advanced Glycation End Product Accumulation, Is a Predictor of Mortality in Hemodialysis Patients. By R. Meerwaldt, R. Graaff, T.P. Links, J.W. Baynes, G.J. Navis, R.M. Huisman, R.O.B. Gans, and A.J. Smit
Short-Term Sugar Exposure Significantly Modifies FGF-2 Structure and Angiogenic Functions: Pathophysiological Implications. F. Facchiano, A. Facchiano, K. Russo, C. Mennella, R. Ragone, D. Ribatti, M.C. Capogrossi, and V. Fogliano
Advanced Glycation End Product-Modified Protein and Alpha,Beta-Dicarbonyls Affect Cisplatin Concentration in Blood. By Kazuhiro Yoshihara, Yoshiaki Nagayama, Kentaro Saito, Hideaki Horiguchi, Satoru Takahashi, Nobuhiko Saito, Shin-Ichiro Yoshida, and Masatoshi Beppu
Protein Glycation Marker Residues and Free Adducts of Cerebrospinal Fluid in Alzheimer's Disease and a Link to Cognitive Impairment. By N. Ahmed, U. Ahmed, K. Hager, G. Fleischer, G. Munch, and P.J. Thornalley
Improvement of the Metabolic Syndrome and Renal Injury by Low-Calorie Diet Is Associated with Renal AGE Reduction in Rat Type 2 Diabetic Mephropathy. By M. Nangaku, R. Inagi, N. Ishikawa, Y. Izuhara, and T. Miyata
Overexpression of GLUT4 in Muscle and heart Leads to Increased Cardiac Myosin Glycation and Early Death: Suppression by Caloric Restriction. By Vincent M. Monnier, Christopher Strauch, Ashwini Viswanathan, David R. Sell, and Roger J. McCarter
Skin Collagen-Linked Fluorescence Predicts Atherosclerosis Progression in the Epidemiology of Diabetes Interventions and Complications (EDIC) Study. By V.M. Monnier, O. Bautista, P. Cleary, D.R. Sell, S. Genuth, and the DCCT/EDIC Research Group
Exogenous Methylglyoxal Induces Diabetes-like Microvascular Changes in Rats. By J. Berlanga, D. Cibrian, I. Guillen, F. Freyre, J.S. Alba, N. Merino, A. Aldama, A.M. Quintela, M.E. Triana, H. Ajameich, P. Lopez, N. Ahmed, and P.J. Thornalley
Association of the Cluster of Genetic Risk Factors in Loci Related to Glycoxidation with Diabetic Nephropathy in Type 2 Diabetes Mellitus. K. Kankova, A. Stejskalova, L. Pacal, M. Hertlova, and D. Krusova
Advanced Glycation End Products and Chemokines in the Serum and Urine of Patients with Chronic Allograft Nephropathy and IgA-Nephropathy--Relation to Chronic Damage and Inflammation. By M. Ruester, S.Franke, and G. Stein
Advanced Glycation End Product Excretion Rates by Peritoneal Dialysis in End-Stage Renal Disease. By S. Agalou, N. Ahmed, A. Dawnay, and P.J. Thornalley
Removal of Free Advanced Glycation End Products by Hemodialysis. By S. Agalou, N. Ahmed, P.J. Thornalley, and A. Dawnay
Effects of Vitamin E alpha on Thrombotic Events and Markers of Oxidation and Inflammation in Hemodialysis. By M.F. Weiss, W.D. Schwing, C. Holloman, C. Siegel, J. Valente, P. Deoreo, P. Erhard, and V.M. Monnier
Ultrapure Dialysate Decreases Plasma Pentosidine, a Marker of Carbonyl Stress, in Hemodialysis Patients. By Yuko Izuhara, Naoyoshi Ishikawa, Reiko Inagi, and Toshio Miyata
Reduced Circulating Age Levels and Lower Genomic Damage in Patients Undergoing Daily versus Standard Hemodialysis. By Evangelia Fragedaki, Michael Nebel, Nicole Schupp, Katarina Sebekova, Wolfgang Volkel, Andre Klassen, Monika Pischetsrieder, Matthias Frischmann, Toshimitsu Niwa, Jorg Vienken, August Heidland, and Helga Stopper
Advanced Glycation End Product-Induced DNA Damage: Involvement of Angiotensin II. By N. Schupp, U. Lakner, K. Sebekova, A. Heidland, and H. Stopper
Interactions between the Renin Angiotensin System and Advanced Glycation in Diabetic Nephropathy. By M.C. Thomas, J.M. Forbes, and M.E. Cooper
Increased Plasma and Urinary Methylglyoxal-Derived Hydroimidazolone in Type 1 Diabetic Patients. By N. Ahmed, R. Babaei-Jadidi, P.J. Thornalley, S.K. Howell, and P.J. Beisswenger
Heavily Oxidized-Glycated LDL Inhibits Tissue Inhibitor of Metalloproteinase-3 Expression in Human Retinal Capillary Pericytes. By Weiwei Song, Kangmo Lu, Yan Huang, Jeremy Barth, Scott Argraves, and Timothy Lyons
Platelet Adhesion to Glycated GFOGER Peptide and Bovine Serum Albumin. By D.A. Slatter and R.W. Farndale
Characterization of a Glycoaldehyde-Modified Model of the Diabetic Basement Membrane: Relevance to Pathological Responses during Diabetes. By Norma Frizzell, Alan W. Stitt, and Suzanne R. Thorpe
Effect of Glucose Concentration on the Formation of Advanced Glycation End Products in Erythrocytes in Vitro. By E.K. Deemer, R. Nagai, J.W.C. Brock, S.R. Thorpe, and J.W. Baynes
The Internalization of 3-Deoxyglucosone in Human Umbilical Vein Endothelial Cells. By H. Sakiyama, M. Takahashi, T. Yamamoto, T. Teshima, and N. Taniguchi
The Effects of Advanced Glycation End Products (AGEs) on Endothelial Cell Nitric Oxide Synthase and Tumor Necrosis Factor-alpha Expression Are AGE Receptor Dependent. By G. Rashid, S. Benchetrit, D. Fishman, and J. Bernheim
Identification of N-Methylpyridinium as a Key Chemopreventive Compound and a RAGE Ligand in Coffee Beverage Usng in Vitro and in Vivo Techniques. By V. Somoza, M. Lindenmeier, E. Wenzel, O. Frank, S. Bek, J. Huber, Weigl, S. Scheidler, A.E. Busch, H.F. Erbersdobler, and T. Hofmann
Prevention of Diabetic Ocular Complications in Spontaneously Diabetic Torii Rats by the Aldose Reductase Inhibitor Fidarestat. By A. Kakehashi, Y. Saito, K. Mori, R. Ono, N. Sugi, H. Yamagami, M. Kuroki, H. Tamemoto, S. Ishikawa, M. Kawakami, Y. Kanazawa, H. Hirooka, and N. Kato
Prevention of Diabetic Ocular Complications in Spontaneously Diabetic Torii Rats by Aminoguanidine. By A. Kakehashi, Y. Saito, K. Mori, R. Ono, N. Sugi, H. Yamagami, M. Kuroki, H. Tamemoto, S. Ishikawa, M. Kawakami, and Y. Kanazawa
Carotenoids as Antioxidants for the Prevention of Diabetic Complications. By K. Tomisaka and N.V. Chuyen
Evidence for Variations in Deglycating Activity among Tissues in the Diabetic Rat. By S.M. Brown, D.M. Smith, S.R. Thorpe, and J.W. Baynes
Green Tea (Camellia sinensis) Ameliorates Retinopathy and Renal Mitochondrial Defects but Deteriorates Collagen Glycoxidation and Cross-Linking in Experimental Diabetes. By Georgian T. Mustata, Mariana G. Rosca, Oliver Reihl, Klaus Biemel, Mark A. Smith, Ashwini Vishwanathan, Christopher Strauch, Yun Peng Du, Timothy S. Kern, Markus Lederer, Michael Brownlee, Miriam F. Weiss, and Vincent M. Monnier
Aspirin Inhibits Pentosidine Formation in Collagen Incubated with Glucose. By P. Urios, A.M. Borsos, C. Girard, and M. Sternberg
Effects on Glycation of Valsartan Therapy in Vivo. By P. Odetti, A. Poggi, F. Monacelli, S. Rossi, A. Durante, M. Cirnigliaro, L. Ricca, and G.L. Viviani
In Vitro and in Vivo Evidence for the AGE-Inhibitory Property of Antihypertensive Agents. By Yuko Izuhara, Naoyoshi Ishikawa, Reiko Inagi, Madaomi Nangaku, and Toshio Miyata
Quantification of Advanced Glycation End Products in Diabetic Animal Tissues by Reverse-Phase-High-Powered Liquid Chromatography: An Investigation of the Role of Pyridoxamine. By Norma Frizzell, Alan W. Stitt, and Suzanne R. Thorpe
Amadori-Lysyl-Induced Propagation of Protein Modifications Is Inhibited by Pyridoxamine. By P.A. Voziyan, S.V. Chetyrkin, and B.G. Hudson
Cleavage of Dicarbonyl Compounds by the Advanced Glycation/Lipidoxidation End Product Inhibitor Pyridoxamine. By M.L. Stroman, T.O. Metz, S.R. Thorpe, and J.W. Baynes
High Glucose and Advanced Glycation End Products Inhibit the Proliferation of Cultured Endothelial Cells: Protection by Vitamin E. By J. Zhang, M. Slevin, Y. Duraisamy, C.A. Smith, J. Gaffney, and N. Ahmed