DNA recombination and repair / edited by Paul J. Smith & Christopher J. Jones.

Includes bibliographical references and index.

Contents;

1. Molecular processing of DNA folding anomalies in Escherichia coli
1. Introduction
2. Folding anomalies in DNA
3. Deletions at direct repeats stimulated by closely spaced inverted repeats
4. Duplications and amplifications of triplet repeats
etc.

2. Double-strand break repair and V (D) recombination
1. Introduction
2. V (D) recombination
3. Mechanisms of DNA double-strand break repair
4. Identification of the genes involved in NHEJ
etc.

3. Translesion replication
1. Introduction
2. Tranlesion replication in E.coli
3. Translesion replication in yeast
4. The mutagenic properties of DNA damage
5. Comparisons, speculations, and TR in humans

4. Mismatch repair and cancer
1. Introduction
2. Bacterial mismatch repair
3. Human mismatch repair
4. Mismatch repair defects in mouse models
etc.

5. Enzymology of human nucleotide excision repair
1. Introduction
2. Human NER factors and general strategies
3. The human genetic framework: xeroderma pigmentosum
4. The biochemical framework: in vitro reconstitution of human NER activity
etc.

6. Transcription-coupled and global genome repair in yeast and humans
1. Introduction
2. Techniques
3. Transcription-coupled nucleotide excision repair
4. Global genome nucleotide excision repair
5. Connections between NER and other repair pathways

7. The ATM gene and stress response
1. Introduction
2. Ataxia-telangiectasia
3. Cloning of ATM
4. The ATM protein
etc.

8. p53 and the integrated response to DNA damage
1. Introduction
2. DNA damage: induction and processing
3. DNA damage induction by anticancer agents
4. Cellular responses to stress and the role of p53
etc.