Understanding pathophysiology / Sue E. Huether, Kathryn L. McCance.

Contributor(s): Publication details: St. Louis, Mo. : Elsevier, c2017.Edition: 1st edDescription: xix, 1150p. : ill. (chiefly col.) ; 28 cmISBN:
  • 9781771721172, 9780323354097
Subject(s): LOC classification:
  • QT 104 T22u 2017
Contents:
CONTENT Part One Basic Concepts of Pathophysiology Unit 1 The Cell 1 Cellular Biology Prokaryotes and Eukaryotes Cellular Functions Structure and Function of Cellular Components Cell-to-Cell Adhesions Cellular Communication and Signal Transduction Cellular Metabolism Membrane Transport: Cellular Intake and Output Cellular Reproduction: The Cell Cycle Tissues 2 Genes and Genetic Diseases DNA, RNA, and Proteins: Heredity at the Molecular Level Chromosomes Elements of Formal Genetics Transmission of Genetic Diseases Linkage Analysis and Gene Mapping Multifactorial Inheritance 3 Epigenetics and Disease Epigenetic Mechanisms Epigenetics and Human Development Genomic Imprinting Inheritance of Epigenetic States Epigenetics and Cancer Future Directions 4 Altered Cellular and Tissue Biology Cellular Adaptation Cellular Injury Manifestations of Cellular Injury: Accumulations Cellular Death Aging and Altered Cellular and Tissue Biology Somatic Death 5 Fluids and Electrolytes, Acids and Bases Distribution of Body Fluids and Electrolytes Alterations in Water Movement Sodium, Chloride, and Water Balance Alterations in Sodium, Chloride, and Water Balance Alterations in Potassium and Other Electrolytes Acid-Base Balance Pediatric Considerations Geriatric Considerations Unit 2 Mechanisms of Self-Defence 6 Innate Immunity Human Defence Mechanisms Acute and Chronic Inflammation Wound Healing Pediatric Considerations Geriatric Considerations 7 Adaptive Immunity Third Line of Defence: Adaptive Immunity Antigens and Immunogens Antibodies Immune Response: Collaboration of B Cells and T Cells Cell-Mediated Immunity Pediatric Considerations Geriatric Considerations 8 Infection and Defects in Mechanisms of Defence Infection Deficiencies in Immunity Hypersensitivity: Allergy, Autoimmunity, and Alloimmunity 9 Stress and Disease Historical Background and General Concepts The Stress Response Stress, Personality, Coping, and Illness Geriatric Considerations Unit 3 Cellular Proliferation: Cancer 10 Biology of Cancer Cancer Terminology and Characteristics The Biology of Cancer Cells Clinical Manifestations of Cancer Diagnosis, Characterization, and Treatment of Cancer 11 Cancer Epidemiology Genetics, Epigenetics, and Tissue Incidence and Mortality Trends In Utero and Early Life Conditions Environmental and Lifestyle Factors 12 Cancer in Children and Adolescents Incidence, Etiology, and Types of Childhood Cancer Prognosis Part Two Body Systems and Diseases Unit 4 The Neurological System 13 Structure and Function of the Neurological System Overview and Organization of the Nervous System Cells of the Nervous System The Nerve Impulse The Central Nervous System The Peripheral Nervous System The Autonomic Nervous System Geriatric Considerations 14 Pain, Temperature, Sleep, and Sensory Function Pain Temperature Regulation Sleep The Special Senses Somatosensory Function Geriatric Considerations Geriatric Considerations Geriatric Considerations 15 Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function Alterations in Cognitive Systems Alterations in Cerebral Hemodynamics Alterations in Neuromotor Function Alterations in Complex Motor Performance Extrapyramidal Motor Syndromes 16 Disorders of the Central and Peripheral Nervous Systems and Neuromuscular Junction Central Nervous System Disorders Peripheral Nervous System and Neuromuscular Junction Disorders Tumours of the Central Nervous System 17 Alterations of Neurological Function in Children Development of the Nervous System in Children References Structural Malformations Alterations in Function: Encephalopathies Cerebrovascular Disease in Children Childhood Tumours Unit 5 The Endocrine System 18 Mechanisms of Hormonal Regulation Mechanisms of Hormonal Regulation Structure and Function of the Endocrine Glands Geriatric Considerations 19 Alterations of Hormonal Regulation Mechanisms of Hormonal Alterations Alterations of the Hypothalamic-Pituitary System Alterations of Thyroid Function Alterations of Parathyroid Function Dysfunction of the Endocrine Pancreas: Diabetes Mellitus Alterations of Adrenal Function Unit 6 The Hematological System 20 Structure and Function of the Hematological System Components of the Hematological System Development of Blood Cells Mechanisms of Hemostasis Pediatric Considerations Geriatric Considerations 21 Alterations of Hematological Function Alterations of Erythrocyte Function Myeloproliferative Red Blood Cell Disorders Alterations of Leukocyte Function Alterations of Lymphoid Function Alterations of Splenic Function Hemorrhagic Disorders and Alterations of Platelets and Coagulation 22 Alterations of Hematological Function in Children Disorders of Erythrocytes Disorders of Coagulation and Platelets Neoplastic Disorders Unit 7 The Cardiovascular and Lymphatic Systems 23 Structure and Function of the Cardiovascular and Lymphatic Systems The Circulatory System The Heart The Systemic Circulation The Lymphatic System 24 Alterations of Cardiovascular Function Diseases of the Veins Diseases of the Arteries Disorders of the Heart Wall Manifestations of Heart Disease Shock 25 Alterations of Cardiovascular Function in Children Congenital Heart Disease Acquired Cardiovascular Disorders Unit 8 The Pulmonary System 26 Structure and Function of the Pulmonary System Structures of the Pulmonary System Function of the Pulmonary System Geriatric Considerations 27 Alterations of Pulmonary Function Clinical Manifestations of Pulmonary Alterations Disorders of the Chest Wall and Pleura Pulmonary Disorders 28 Alterations of Pulmonary Function in Children Disorders of the Upper Airways Disorders of the Lower Airways Sudden Unexpected Infant Death Unit 9 The Renal and Urological Systems 29 Structure and Function of the Renal and Urological Systems Structures of the Renal System Renal Blood Flow Kidney Function Tests of Renal Function Pediatric Considerations Geriatric Considerations 30 Alterations of Renal and Urinary Tract Function Urinary Tract Obstruction Urinary Tract Infection Glomerular Disorders Acute Kidney Injury Chronic Kidney Disease 31 Alterations of Renal and Urinary Tract Function in Children Structural Abnormalities Glomerular Disorders Nephroblastoma Bladder Disorders Urinary Incontinence Unit 10 The Reproductive Systems 32 Structure and Function of the Reproductive Systems Development of the Reproductive Systems The Female Reproductive System Structure and Function of the Breast The Male Reproductive System Aging and Reproductive Function 33 Alterations of the Female Reproductive System Abnormalities of the Female Reproductive Tract Alterations of Sexual Maturation Disorders of the Female Reproductive System Disorders of the Female Breast 34 Alterations of the Male Reproductive System Alterations of Sexual Maturation Disorders of the Male Reproductive System References Disorders of the Male Breast Sexually Transmitted Infections Unit 11 The Digestive System 35 Structure and Function of the Digestive System The Gastro-Intestinal Tract Accessory Organs of Digestion Geriatric Considerations 36 Alterations of Digestive Function Disorders of the Gastro-Intestinal Tract Disorders of the Accessory Organs of Digestion Cancer of the Digestive System 37 Alterations of Digestive Function in Children Disorders of the Gastro-Intestinal Tract Disorders of the Liver Gastro-Intestinal Malignancies in Children Unit 12 The Musculo-skeletal and Integumentary Systems 38 Structure and Function of the Musculo-skeletal System Structure and Function of Bones Structure and Function of Joints Structure and Function of Skeletal Muscles Aging and the Musculo-skeletal System 39 Alterations of Musculo-skeletal Function Musculo-skeletal Injuries Disorders of Bones Disorders of Joints Disorders of Skeletal Muscle Musculo-skeletal Tumours 40 Alterations of Musculo-skeletal Function in Children Congenital Defects Bone Infection Juvenile Idiopathic Arthritis Osteochondroses Scoliosis Muscular Dystrophy Musculo-skeletal Tumours Nonaccidental Trauma 41 Structure, Function, and Disorders of the Integument Structure and Function of the Skin Disorders of the Skin Disorders of the Hair Disorders of the Nail Geriatric Considerations 42 Alterations of the Integument in Children Acne Vulgaris Dermatitis Infections of the Skin Insect Bites and Parasites Cutaneous Hemangiomas and Vascular Malformations Other Skin Disorders Index
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Book Closed Access Book Closed Access Health Sciences Library QT 104 T22u 2017 (Browse shelf(Opens below)) 1 Available MBAL23070241

Includes Index: 1119-1150

CONTENT

Part One Basic Concepts of Pathophysiology
Unit 1 The Cell

1 Cellular Biology
Prokaryotes and Eukaryotes
Cellular Functions
Structure and Function of Cellular Components
Cell-to-Cell Adhesions
Cellular Communication and Signal Transduction
Cellular Metabolism
Membrane Transport: Cellular Intake and Output
Cellular Reproduction: The Cell Cycle
Tissues


2 Genes and Genetic Diseases
DNA, RNA, and Proteins: Heredity at the Molecular Level
Chromosomes
Elements of Formal Genetics
Transmission of Genetic Diseases
Linkage Analysis and Gene Mapping
Multifactorial Inheritance

3 Epigenetics and Disease
Epigenetic Mechanisms
Epigenetics and Human Development
Genomic Imprinting
Inheritance of Epigenetic States
Epigenetics and Cancer
Future Directions

4 Altered Cellular and Tissue Biology
Cellular Adaptation
Cellular Injury
Manifestations of Cellular Injury: Accumulations
Cellular Death
Aging and Altered Cellular and Tissue Biology
Somatic Death

5 Fluids and Electrolytes, Acids and Bases
Distribution of Body Fluids and Electrolytes
Alterations in Water Movement
Sodium, Chloride, and Water Balance
Alterations in Sodium, Chloride, and Water Balance
Alterations in Potassium and Other Electrolytes
Acid-Base Balance
Pediatric Considerations
Geriatric Considerations

Unit 2 Mechanisms of Self-Defence
6 Innate Immunity
Human Defence Mechanisms
Acute and Chronic Inflammation
Wound Healing
Pediatric Considerations
Geriatric Considerations

7 Adaptive Immunity
Third Line of Defence: Adaptive Immunity
Antigens and Immunogens
Antibodies
Immune Response: Collaboration of B Cells and T Cells
Cell-Mediated Immunity
Pediatric Considerations
Geriatric Considerations

8 Infection and Defects in Mechanisms of Defence
Infection
Deficiencies in Immunity
Hypersensitivity: Allergy, Autoimmunity, and Alloimmunity

9 Stress and Disease
Historical Background and General Concepts
The Stress Response
Stress, Personality, Coping, and Illness
Geriatric Considerations

Unit 3 Cellular Proliferation: Cancer
10 Biology of Cancer
Cancer Terminology and Characteristics
The Biology of Cancer Cells
Clinical Manifestations of Cancer
Diagnosis, Characterization, and Treatment of Cancer

11 Cancer Epidemiology
Genetics, Epigenetics, and Tissue
Incidence and Mortality Trends
In Utero and Early Life Conditions
Environmental and Lifestyle Factors

12 Cancer in Children and Adolescents
Incidence, Etiology, and Types of Childhood Cancer
Prognosis

Part Two Body Systems and Diseases
Unit 4 The Neurological System

13 Structure and Function of the Neurological System
Overview and Organization of the Nervous System
Cells of the Nervous System
The Nerve Impulse
The Central Nervous System
The Peripheral Nervous System
The Autonomic Nervous System
Geriatric Considerations

14 Pain, Temperature, Sleep, and Sensory Function
Pain
Temperature Regulation
Sleep
The Special Senses
Somatosensory Function
Geriatric Considerations
Geriatric Considerations
Geriatric Considerations

15 Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function
Alterations in Cognitive Systems
Alterations in Cerebral Hemodynamics
Alterations in Neuromotor Function
Alterations in Complex Motor Performance
Extrapyramidal Motor Syndromes

16 Disorders of the Central and Peripheral Nervous Systems and Neuromuscular Junction
Central Nervous System Disorders
Peripheral Nervous System and Neuromuscular Junction Disorders
Tumours of the Central Nervous System

17 Alterations of Neurological Function in Children
Development of the Nervous System in Children
References
Structural Malformations
Alterations in Function: Encephalopathies
Cerebrovascular Disease in Children
Childhood Tumours

Unit 5 The Endocrine System
18 Mechanisms of Hormonal Regulation
Mechanisms of Hormonal Regulation
Structure and Function of the Endocrine Glands
Geriatric Considerations

19 Alterations of Hormonal Regulation
Mechanisms of Hormonal Alterations
Alterations of the Hypothalamic-Pituitary System
Alterations of Thyroid Function
Alterations of Parathyroid Function
Dysfunction of the Endocrine Pancreas: Diabetes Mellitus
Alterations of Adrenal Function

Unit 6 The Hematological System
20 Structure and Function of the Hematological System
Components of the Hematological System
Development of Blood Cells
Mechanisms of Hemostasis
Pediatric Considerations
Geriatric Considerations

21 Alterations of Hematological Function
Alterations of Erythrocyte Function
Myeloproliferative Red Blood Cell Disorders
Alterations of Leukocyte Function
Alterations of Lymphoid Function
Alterations of Splenic Function
Hemorrhagic Disorders and Alterations of Platelets and Coagulation

22 Alterations of Hematological Function in Children
Disorders of Erythrocytes
Disorders of Coagulation and Platelets
Neoplastic Disorders

Unit 7 The Cardiovascular and Lymphatic Systems
23 Structure and Function of the Cardiovascular and Lymphatic Systems
The Circulatory System
The Heart
The Systemic Circulation
The Lymphatic System

24 Alterations of Cardiovascular Function
Diseases of the Veins
Diseases of the Arteries
Disorders of the Heart Wall
Manifestations of Heart Disease
Shock

25 Alterations of Cardiovascular Function in Children
Congenital Heart Disease
Acquired Cardiovascular Disorders

Unit 8 The Pulmonary System
26 Structure and Function of the Pulmonary System
Structures of the Pulmonary System
Function of the Pulmonary System
Geriatric Considerations

27 Alterations of Pulmonary Function
Clinical Manifestations of Pulmonary Alterations
Disorders of the Chest Wall and Pleura
Pulmonary Disorders

28 Alterations of Pulmonary Function in Children
Disorders of the Upper Airways
Disorders of the Lower Airways
Sudden Unexpected Infant Death

Unit 9 The Renal and Urological Systems
29 Structure and Function of the Renal and Urological Systems
Structures of the Renal System
Renal Blood Flow
Kidney Function
Tests of Renal Function
Pediatric Considerations
Geriatric Considerations

30 Alterations of Renal and Urinary Tract Function
Urinary Tract Obstruction
Urinary Tract Infection
Glomerular Disorders
Acute Kidney Injury
Chronic Kidney Disease

31 Alterations of Renal and Urinary Tract Function in Children
Structural Abnormalities
Glomerular Disorders
Nephroblastoma
Bladder Disorders
Urinary Incontinence

Unit 10 The Reproductive Systems
32 Structure and Function of the Reproductive Systems
Development of the Reproductive Systems
The Female Reproductive System
Structure and Function of the Breast
The Male Reproductive System
Aging and Reproductive Function

33 Alterations of the Female Reproductive System
Abnormalities of the Female Reproductive Tract
Alterations of Sexual Maturation
Disorders of the Female Reproductive System
Disorders of the Female Breast

34 Alterations of the Male Reproductive System
Alterations of Sexual Maturation
Disorders of the Male Reproductive System
References
Disorders of the Male Breast
Sexually Transmitted Infections

Unit 11 The Digestive System
35 Structure and Function of the Digestive System
The Gastro-Intestinal Tract
Accessory Organs of Digestion
Geriatric Considerations

36 Alterations of Digestive Function
Disorders of the Gastro-Intestinal Tract
Disorders of the Accessory Organs of Digestion
Cancer of the Digestive System

37 Alterations of Digestive Function in Children
Disorders of the Gastro-Intestinal Tract
Disorders of the Liver
Gastro-Intestinal Malignancies in Children

Unit 12 The Musculo-skeletal and Integumentary Systems
38 Structure and Function of the Musculo-skeletal System
Structure and Function of Bones
Structure and Function of Joints
Structure and Function of Skeletal Muscles
Aging and the Musculo-skeletal System

39 Alterations of Musculo-skeletal Function
Musculo-skeletal Injuries
Disorders of Bones
Disorders of Joints
Disorders of Skeletal Muscle
Musculo-skeletal Tumours

40 Alterations of Musculo-skeletal Function in Children
Congenital Defects
Bone Infection
Juvenile Idiopathic Arthritis
Osteochondroses
Scoliosis
Muscular Dystrophy
Musculo-skeletal Tumours
Nonaccidental Trauma

41 Structure, Function, and Disorders of the Integument
Structure and Function of the Skin
Disorders of the Skin
Disorders of the Hair
Disorders of the Nail
Geriatric Considerations

42 Alterations of the Integument in Children
Acne Vulgaris
Dermatitis
Infections of the Skin
Insect Bites and Parasites
Cutaneous Hemangiomas and Vascular Malformations
Other Skin Disorders

Index

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