Principles of bone biology / edited by John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan.

Contents;

Volume one
1. Basic principles
A. Cell biology
Structure and development of the skeleton
Biomechanics
Embryonic development of bone and the molecular regulation and endochondral bone formation
Mesenchymal stem cells and osteoblast differentiation
Transcriptional control of osteoblast differentiation and function
etc.

B. Biochemistry
Type I collagen: Structure, synthesis and regulation
Collagen cross-linking and metabolism
Bone matrix proteoglycans
Osteopontin
Bone proteinases
Integrins and other cell surface attachment molecules of bone cells
etc.

C. Bone remodeling and mineral homeostasis
Histomorphometric analysis of bone remodeling
Phosphorus homeostasis and related disorders
Magnesium homeostasis
Metals in bone: Aluminum, boron, cadmium, chromium, lead, silicon and strontium
etc.

D. The hormones of bone
Receptors for parathyroid hormone(PTH) and PTH-related peptide
Parathyroid hormone: Molecular biology
Parathyroid hormone: Receptor interactions
etc.

Volume two
Vascular endothelial growth factors
Transforming growth factor
Bone morphogenetic proteins
Bone morphogenetic protein receptors and actions
etc.

2. Molecular mechanisms of metabolic bone diseases
Molecular basis of PTH overexpression
Familial benign hypocalciuric hypercalcemia and neonatal primary hyperparathyroidism
Multiple endocrine neoplasia type I
etc.

3. Pharmacological mechanisms of therapeutic
Parathyroid hormone Calcium
Calcium receptors as novel drug targets
Bisphosphonates mechanisms of action
Fluoride in osteoporosis
etc.

4. Methods in bone research
Application of transgenic mice to problems of skeletal biology
Use of cultured osteoblastic cells to identify and characterize transcriptional regulatory complexes
Current methodologic issues in cell tissue culture
Biochemical markers of bone metabolism
etc.

Includes bibliographical references and index.