MARC details
| 000 -LEADER |
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| fixed length control field |
03283pam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20231013123057.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
960715m19972002nyua b 001 0 eng c |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
0080423019 (hc : alk. paper) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
0444508686 (v. 14) |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
BUL |
| Transcribing agency |
BUL |
| Modifying agency |
BUL |
| Language of cataloging |
eng |
| Description conventions |
rda |
| 060 10 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER |
|---|
| Classification number |
QV 600 C737 2002 |
| 245 00 - TITLE STATEMENT |
|---|
| Title |
Comprehensive toxicology / |
| Statement of responsibility, etc. |
editors-in-chief, I. Glenn Sipes, Charlene A. McQueen, A. Jay Gandolfi. |
| 250 ## - EDITION STATEMENT |
|---|
| Edition statement |
1st edition |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Amsterdam : |
| Name of publisher, distributor, etc. |
Elsevier, |
| Date of publication, distribution, etc. |
c2002. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
14 v. : |
| Other physical details |
ill. ; |
| Dimensions |
28 cm. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc. note |
Includes bibliographical references and index. |
| 505 ## - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Contents<br/><br/>Preface. <br/>Contributors to Volume 14.<br/> Introduction. <br/><br/>1. Basic Concepts. <br/>Introduction to molecular toxicology. <br/>Exposure-Dose-Response: a molecular perspective.<br/>Receptor theory and the ligand-macromolecule complex. <br/>Control of gene expression. <br/><br/>2. Xenobiotic Receptor Systems. <br/>Introduction and overview. <br/>The Per-Arnt-Sim (PAS) protein superfamily. <br/>The Aryl hydrocarbon receptor: a model of gene-environment interactions.<br/>Peroxisomes, peroxisome proliferators and peroxisome proliferator-activated receptors (PPARs). <br/>The physiological role of Pregnane-X-Receptor (PXR) in xenobiotic and bile acid homeostasis. <br/>Regulation of phenobarbital responsiveness via the Constitutive Androstane Receptor (CAR).<br/>Mechanisms of metal-induction of metallothionein gene expression. <br/>Modulation of soluble receptor signaling by coregulators. <br/>Convergence of multiple nuclear receptor signaling pathways in the mediation of xenobiotic-induced nongenotoxic carcinogenesis. <br/><br/>3. Genetic Determinants of Susceptibility to Environmental Agents.<br/>Introduction and overview. <br/>Molecular biomarkers for human liver cancer. <br/>Inherited susceptibility and prostate cancer risk. <br/>Modeling genetic susceptibility to cancer in the mouse. <br/>DNA methylation and gene silencing.<br/><br/>4. Alterations of Cell Signaling by Xenobiotics. <br/>Introduction and overview. <br/>Mitogen-Activated Protein Kinase (MAPK) signal transduction pathways regulated by stresses and toxicants. <br/>Antioxidant induction of genes encoding detoxifying enzymes. <br/>Hypoxia regulation of gene expression through HIF1 signaling. <br/>Epigenetic-toxicant induced modulated gap junctional intercellular communication. <br/>Environmental influences on cell cycle regulation. <br/>Biochemical signals that initiate apoptosis. <br/><br/>5. Emerging Technologies and Predictive Assays.<br/>Introduction and overview. <br/>Bioinformatics. <br/>Interpretation of toxicogenomic data using genetically-altered mice.<br/>Gene expression analysis in the Microarray Age. <br/>Proteomic applications in toxicology. <br/>Metabonomic technology as a tool for rapid throughput in vivo toxicity screening.<br/>Data mining in toxicology.<br/>Appendix I. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Toxicology. |
| 650 12 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Poisons. |
| 650 22 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Poisoning. |
| 650 22 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Toxicity Tests. |
| 650 22 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Toxicology |
| General subdivision |
methods. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sipes, I. Glenn. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
McQueen, Charlene A., |
| Dates associated with a name |
1947- |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Gandolfi, A. Jay. |
| 856 42 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Materials specified |
Publisher description |
| Uniform Resource Identifier |
<a href="http://www.loc.gov/catdir/enhancements/fy0601/96033052-d.html">http://www.loc.gov/catdir/enhancements/fy0601/96033052-d.html</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Book Open Access |
| Edition |
1st edition |
| Classification part |
QV 600 C737 2002 |
| Item part |
1 |
| Call number prefix |
QV 600 |
| Call number suffix |
C737 2002 |
