Surrogate tissue analysis : genomic, proteomic and metabolomic approaches /
Surrogate tissue analysis : genomic, proteomic and metabolomic approaches /
edited by Michael E. Burczynski and John C. Rockett.
- Boca Raton : CRC Press, 2006.
- 306 p. : ill. (some col.) ; 25 cm.
Includes bibliographical references and index.
Table of Contents
SECTION 1 Introduction to Surrogate Tissue Analysis
Chapter 1
Introduction to Surrogate Tissue Analysis
John Rockett
SECTION 2 Genomic Approaches
Chapter 2
Impact of Sample Handling and Preparation on Gene Signatures as Exemplified
for Transcriptome Analysis of Peripheral Blood
Joachim L. Schultze, Svenja Debey, Raji Pillai, Thomas Zander
Chapter 3
Blood Genomic Fingerprints of Brain Diseases ...........................................
Yang Tang, Donald L. Gilbert, Tracy A. Glauser, Andrew D. Hershey, Aigang Lu, Ruiqiong Ran, Huichun Xu and Frank R. Sharp
Chapter 4
Transcriptional Profiling of Peripheral Blood in Oncology
Michael E. Burczynski
Chapter 5
Blood-Derived Transcriptomic Profiles as a Means to Monitor Levels of
Toxicant Exposure and the Effects of Toxicants on Inaccessible Target Tissues
John Rockett
Chapter 6
Spermatozoal RNAs As Surrogate Markers Of Paternal Exposure
G. Charles Ostermeier and Stephen A. Krawetz
SECTION 3 Proteomic Approaches
Chapter 7
Mass Spectrometry Based Profiling for Cancer Detection and Stratification
Emanuel F. Petricoin III, Katherine R. Calvo, Julia Wulfkuhle, and Lance A. Liotta
Chapter 8
Lymphocyte Integrins: Potential Surrogate Biomarkers for Evaluation of
Endometrial Receptivity
K.V. R. Reddy, Sadhana Gupta and P. K. Meherji
Chapter 9
Nipple Aspirate Fluid to Diagnose Breast Cancer and Monitor Response to
Treatment
Edward Sauter
SECTION 4 Metabolomics and Other Approaches
Chapter 10
Metabonomics: Metabolic Profiling and Pattern Recognition Analysis of Body
Fluids and Tissues for Characterisation of Drug Toxicity and Disease Diagnosis ......
Julian L. Griffin and Nigel J. Waters
Chapter 11
Comprehensive Metabolomic Profiling of Serum and Cerebrospinal Fluid:
Understanding Disease, Human Variability and Toxicity ..................................
Shawn Ritchie
Chapter 12
Lipidomic Analysis of Plasma and Tissues: Lipid-Derived Mediators of
Inflammation and Markers of Disease
Clary B. Clish and Charles N. Serhan
Chapter 13
Molecular Detection and Characterization of Circulating Tumor Cells and Micrometastases in Solid Tumor Settings
Ronald A. Ghossein, Hikmat Al-Ahmadie, and Satyajit Bhattacharya
Chapter 14
Methylation Profiling of Tumor Cells and Tumor DNA in Blood, Urine and
Body Fluids for Cancer Detection and Monitoring
Ivy H. N. Wong
SECTION 5 Future Considerations for Surrogate Tissue Profiling
Chapter 15
Regulatory and Technical Challenges in Incorporating Surrogate Tissue
Profiling Strategies into Clinical Development Programs
Judith L. Oestreicher, Monica J. Cahilly, Deborah P. Mounts, Maryann Z. Whitley, Lisa A. Speicher, William L. Trepicchio and Michael E. Burczynski
Chapter 16
Considerations in the Economic Assessment of the Value of Molecular Profiling
Sarah C. Stallings
Chapter 17
The Impact and Challenges of Pan-Omic Approaches in Pharmaceutical Discovery
and Development
William D. Pennie, Jennifer L. Colangelo and Michael P. Lawton
Chapter 18
Current and Future Aspects of Surrogate Tissue Analysis
Michael Burczynski
0849328403 9780849328404
Biochemical markers.
Genomics.
Proteomics.
Biological Markers--analysis.
Genetic Techniques.
Genomics--methods.
Metabolism.
Proteomics--methods.
QW 470 S962 2006
Includes bibliographical references and index.
Table of Contents
SECTION 1 Introduction to Surrogate Tissue Analysis
Chapter 1
Introduction to Surrogate Tissue Analysis
John Rockett
SECTION 2 Genomic Approaches
Chapter 2
Impact of Sample Handling and Preparation on Gene Signatures as Exemplified
for Transcriptome Analysis of Peripheral Blood
Joachim L. Schultze, Svenja Debey, Raji Pillai, Thomas Zander
Chapter 3
Blood Genomic Fingerprints of Brain Diseases ...........................................
Yang Tang, Donald L. Gilbert, Tracy A. Glauser, Andrew D. Hershey, Aigang Lu, Ruiqiong Ran, Huichun Xu and Frank R. Sharp
Chapter 4
Transcriptional Profiling of Peripheral Blood in Oncology
Michael E. Burczynski
Chapter 5
Blood-Derived Transcriptomic Profiles as a Means to Monitor Levels of
Toxicant Exposure and the Effects of Toxicants on Inaccessible Target Tissues
John Rockett
Chapter 6
Spermatozoal RNAs As Surrogate Markers Of Paternal Exposure
G. Charles Ostermeier and Stephen A. Krawetz
SECTION 3 Proteomic Approaches
Chapter 7
Mass Spectrometry Based Profiling for Cancer Detection and Stratification
Emanuel F. Petricoin III, Katherine R. Calvo, Julia Wulfkuhle, and Lance A. Liotta
Chapter 8
Lymphocyte Integrins: Potential Surrogate Biomarkers for Evaluation of
Endometrial Receptivity
K.V. R. Reddy, Sadhana Gupta and P. K. Meherji
Chapter 9
Nipple Aspirate Fluid to Diagnose Breast Cancer and Monitor Response to
Treatment
Edward Sauter
SECTION 4 Metabolomics and Other Approaches
Chapter 10
Metabonomics: Metabolic Profiling and Pattern Recognition Analysis of Body
Fluids and Tissues for Characterisation of Drug Toxicity and Disease Diagnosis ......
Julian L. Griffin and Nigel J. Waters
Chapter 11
Comprehensive Metabolomic Profiling of Serum and Cerebrospinal Fluid:
Understanding Disease, Human Variability and Toxicity ..................................
Shawn Ritchie
Chapter 12
Lipidomic Analysis of Plasma and Tissues: Lipid-Derived Mediators of
Inflammation and Markers of Disease
Clary B. Clish and Charles N. Serhan
Chapter 13
Molecular Detection and Characterization of Circulating Tumor Cells and Micrometastases in Solid Tumor Settings
Ronald A. Ghossein, Hikmat Al-Ahmadie, and Satyajit Bhattacharya
Chapter 14
Methylation Profiling of Tumor Cells and Tumor DNA in Blood, Urine and
Body Fluids for Cancer Detection and Monitoring
Ivy H. N. Wong
SECTION 5 Future Considerations for Surrogate Tissue Profiling
Chapter 15
Regulatory and Technical Challenges in Incorporating Surrogate Tissue
Profiling Strategies into Clinical Development Programs
Judith L. Oestreicher, Monica J. Cahilly, Deborah P. Mounts, Maryann Z. Whitley, Lisa A. Speicher, William L. Trepicchio and Michael E. Burczynski
Chapter 16
Considerations in the Economic Assessment of the Value of Molecular Profiling
Sarah C. Stallings
Chapter 17
The Impact and Challenges of Pan-Omic Approaches in Pharmaceutical Discovery
and Development
William D. Pennie, Jennifer L. Colangelo and Michael P. Lawton
Chapter 18
Current and Future Aspects of Surrogate Tissue Analysis
Michael Burczynski
0849328403 9780849328404
Biochemical markers.
Genomics.
Proteomics.
Biological Markers--analysis.
Genetic Techniques.
Genomics--methods.
Metabolism.
Proteomics--methods.
QW 470 S962 2006