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Schijns, Virgil E. J. C.

Immunopotentiators in modern vaccines / Virgil E.J.C. Schijns, Derek T. O'Hagan. - Amsterdam ; Boston : Elsevier Academic Press, c2006. - xi, 371 p. : ill. ; 26 cm.

Contents

Contents
Part I. Perspective on Immunological mechanisms underlying adjuvant activity
1) Unravelling "the immunologist's dirty little secret"
Virgil Schijns

Part II. Host-derived immunopotentiators
2) Dendritic cells as targets and tools in vaccines
Filippo Belardelli, Imerio Capone and Paoloa Rizza
3) Host derived molecules and antibodies against them as adjuvants
Tom Barr, Jennifer Carlring, Andrew W. Heath,

Part III. Natural and synthetic immunopotentiators
4) Immune potentiator mechanisms
Nick Valiante
5) CpG Oligodeoxynucleotides as vaccine adjuvants
Michael J. McCluskie and Risini D. Weeratna
6) Toll-like receptor 4 agonists as vaccine adjuvants
David Persing, Patrick McGowan, Jay T. Evans, Christopher Cluff, Sally Mossman, David Johnson and Jory R. Baldridge
7) Immunomodulatory adjuvants from Quillaja saponaria
Charlotte Read Kensil

Part IV. Particulate immunopotentiators and delivery systems
8) Microparticles as vaccine delivery systems
Derek T. O'Hagan
9) MF59: A safe and potent adjuvant for human use
Audino Podda , Giuseppe Del Guidice and Derek T. O'Hagan
10) Development and evaluation of AS04, an novel an improved adjuvant system containing MPL and aluminium salt
Nathalie Garcon, Marcelle van Mechelen and Martine Wettendorf
11) Virosomes for vaccine delivery
Ian C. Metcalfe and Reinhard Gluck
12) The ISCOMATRIXTM adjuvant
Debbie Drane and Martin Pearse
13) Mineral adjuvants
Erik B. Lindblad

Part V. Mucosal/ non-parenteral adjuvants
14) Mucosal Adjuvants Based On Cholera Toxin and Escherichia Coli Heat-Labile Enterotoxin
Jan Holmgren
15) Transcutaneous Immunization using the Heat-labile Enterotoxin of E. coli as an Adjuvant
Richard T. Kenney and Gregory M. Glenn
VI. Th-1/ CTL adjuvants
16) T cell adjuvants and novel strategies for their identification
Philippe Moingeon

Part VII. Adjuvants in non-infectious disease vaccines
17) Vaccination to treat non-infectious diseases: surveying the opportunities
Stephen W. Martin and Martin F Bachmann

Part VIII. Clinical Practice
18) Clinical evaluation of adjuvants
Robert Edelman and Jakub K Simon
19) Non-clinical safety assessment of vaccines
Elizabeth M Sutkowski and Marion F Gruber

Includes bibliographical references and index.

ISBN: 0120884038 (alk. paper) 9780120884032 (alk. paper)

Subjects--Topical Terms:
Immunological adjuvants.
Immune response--Regulation.
Vaccines.
Vaccines--immunology.
Adjuvants, Immunologic.
Drug Delivery Systems.
Immunotherapy.

Dewey Class. No.: 615.372 / SCH

National Library of Medicine Call No.: QW 805 / I337 2006