000			03254cam a22003734a 4500
001			12398169
003			OSt
005			20240115073116.0
008			010503s2002 caua b 001 0 eng
010			_a 2001090660
020			_a9780120986538
020			_a0120986531 (v. 1 : alk. paper)
020			_a9780120986521
020			_a0120986523 (set : alk. paper)
040			_aBUL _cBUL _dBUL _beng _erda
042			_apcc
082	0	0	_a573.1556 _222 _bPRI
245	1	0	_aPrinciples of bone biology / _cedited by John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan.
250			_a2nd edition.
260			_aSan Diego : _bAcademic Press, _cc2002.
300			_axxiv, 882 p. : _bill. ; _c29 cm.
440			_nvol. 1 ; vol. 2.
500			_aContents; Volume one 1. Basic principles A. Cell biology Structure and development of the skeleton Biomechanics Embryonic development of bone and the molecular regulation and endochondral bone formation Mesenchymal stem cells and osteoblast differentiation Transcriptional control of osteoblast differentiation and function etc. B. Biochemistry Type I collagen: Structure, synthesis and regulation Collagen cross-linking and metabolism Bone matrix proteoglycans Osteopontin Bone proteinases Integrins and other cell surface attachment molecules of bone cells etc. C. Bone remodeling and mineral homeostasis Histomorphometric analysis of bone remodeling Phosphorus homeostasis and related disorders Magnesium homeostasis Metals in bone: Aluminum, boron, cadmium, chromium, lead, silicon and strontium etc. D. The hormones of bone Receptors for parathyroid hormone(PTH) and PTH-related peptide Parathyroid hormone: Molecular biology Parathyroid hormone: Receptor interactions etc. Volume two Vascular endothelial growth factors Transforming growth factor Bone morphogenetic proteins Bone morphogenetic protein receptors and actions etc. 2. Molecular mechanisms of metabolic bone diseases Molecular basis of PTH overexpression Familial benign hypocalciuric hypercalcemia and neonatal primary hyperparathyroidism Multiple endocrine neoplasia type I etc. 3. Pharmacological mechanisms of therapeutic Parathyroid hormone Calcium Calcium receptors as novel drug targets Bisphosphonates mechanisms of action Fluoride in osteoporosis etc. 4. Methods in bone research Application of transgenic mice to problems of skeletal biology Use of cultured osteoblastic cells to identify and characterize transcriptional regulatory complexes Current methodologic issues in cell tissue culture Biochemical markers of bone metabolism etc.
504			_aIncludes bibliographical references and index.
650		0	_aBones _xPhysiology.
650		0	_aBones _xMolecular aspects.
700	1		_aBilezikian, John P.
700	1		_aRaisz, Lawrence G. _q(Lawrence Gideon),
700	1		_aRodan, Gideon A.
856	4	2	_3Publisher description _uhttp://www.loc.gov/catdir/description/els031/2001090660.html
856	4	1	_3Table of contents _uhttp://www.loc.gov/catdir/toc/els031/2001090660.html
942			_2ddc _cBO _e2nd edition _h573.1556 _i1 _kPRI _m573.1556 PRI
999			_c11268 _d11268