Nonviral vectors for gene therapy / edited by Leaf Huang, Mien-chie Hung, Ernst Wagner. - San Diego, CA : Academic Press, c1999. - xxv, 442 p. : ill. (some col.) ; 24 cm.

Includes bibliographical references and index.

Contents

Part I: Introduction
Chapter 1: Introduction, L.Huang and E. Viroonhatapan.

Part II: Cationic Liposomes:
Chapter 2: Progress in Gene Delivery Research and Development, P. Felgner.
Chapter 3: Cationic Lipid-Mediated Gene Delivery to the Airways, J. Marshall, N. Yew, S. Eastman, C. Jiang, R. Scheule, S. Cheng.
Chapter 4: Structure and Structure-Activity Relationship of Lipid-Based Gene Delivery Systems, D. Lasic.
Chapter 5: Self-Assembled Structures of Lipid/DNA Nonviral Gene Delivery Systems from Synchorotron X-Ray Diffraction, C. Safinya, I. Koltover.
Chapter 6: Sites of Uptake and Expression of Cationic Liposome/DNA Complexes Injected Intravenously, J. McLean, G. Thurston, D. McDonald.

Part III: Other Vectors:
Chapter 7: Nuclear Transport of Exogenous DNA, M. Sebestye;n and J. Wolff.
Chapter 8: Particle-Mediated Gene Delivery: Applications to Canine and Other Larger Animal Systems, N.-S. Yang, G. Hogge, E.G. MacEwen.
Chapter 9: Polyethylenimines: A Family of Potent Polymers for Nucleic Acid Delivery, A. Kichler, J.-P. Behr, P. Erbacher.
Chapter 10: Ligand-Polycation Conjugates for Receptor-Targeted Gene Transfer, E. Wagner.
Chapter 11: The Perplexing Delivery Mechanism of Lipoplexes, L. Barron and F. Szoka, Jr..
Chapter 12: Biopolymer-DNA Nanospheres, K. Leong.
Chapter 13: Novel Lipidic Vectors for Gene Transfer, S. Li, L. Huang.

Part IV: Animal Models and Clinical Trials:
Chapter 14: Mechanisms of Cationic Liposome-Mediated Transfection of the Lung Endothelium, D. Liu, J. Knapp, Y. Song.
Chapter 15: Cystic Fibrosis Gene Therapy, U. Griesenbach, D. Geddes, E. Alton.
Chapter 16: Targeting HER-2/neu-Overexpressing Cancer Cells with Transcriptional Repressor Genes Delivered by Cationic Liposome, M.-C. Hung, S.-C. Wang, G. Hortobagyi.
Chapter 17: Immune Pathways Used in Nucleic Acid Vaccination, G. Rhodes.
Chapter 18: A Novel Gene Regulatory System, S. Chua, M. Burcin, Y. Wang, S. Tsai.


0123584655 9780123584656


Gene therapy.
Genetic vectors.
DNA-ligand interactions.
Liposomes.
Drug targeting.

QU 560 N814 1999 / N814 1999