Acid related diseases : biology and treatment /
Irvin M. Modlin, George Sachs.
- 2nd edition.
- Philadelphia : Lippincott Williams & Wilkins, c2004.
- xvii, 522 p. : ill. ; 26 cm.
Includes bibliographical references.
Contents The Production of Acid in the Stomach The Discovery of Acid. From antiquity to the 18th century "The nature of digestive agents Prout and the proton . The Discovery of Ion Pumps Bioenergetics and chemi-osmosis PATPases Ion-Motive Adenosine Triphosphatases Multimeric pumps Oligomeric pumps The Gastric Acid Pump Reaction pathway of the HIK ATPase . Kinetics of the H,K ATPase . Membrane potential and the 2D structure of the gastric HKATPase The Regulation of Gastric Acid Secretion Towards an Understanding of the Physiology of the Stomach "Gastric fistulae: a unique opportunity "Ln milieu interieur" Defining gastric secretion Concepts of digestion Vagal function and gastric function Ulcer models and EGF The role of histamine The discovery of hormones Gastric Acid Secretion Central regulation Neural regulation o acid secretion Paracrine regulation . Endocrine regulation Control ofgastric acidity Cellular regulation 8. G cells D cells Knockout m odels . The Parietal C ell Development of the parietal cell Morphology of the parietal cell . Receptors intracellular signals Activation of the HK ATPase Assembly and trafficking of the H,K ATPase Synthesis and turnover of the H,K ATPase Parietal cell homeostasis Pharmacology of acid secretion History of Therapeutic Approaches to Acid Related Diseases The evolution of therapy Diet Surgery . Gastroprotection Receptor pharmacology Proton pump inhibitors . Inhibition of the Histamine-2 Receptor . Fistamine antagonists The histamine-2 receptor . Pharmacology of the receptor Inhibition of the Gastric Acid Pump P2-type ATPases Targets of the PPIs The substituted pyridal methylsulfinyl benzimidazoles Reversal of acid-secretory inhibition Improvement of PPI profile Therapy with PPIs Mechanism of acid pump antagonists The Biology of Acid Related Disease. The Barriers of the Upper Gastrointestinal Tract . Introduction H istorical aspects The esophageal epithelium Esophageal healing Rationale for treatment of GERD with PPIs The gastric epithelium Duodenal barrier Intragastric pH Hypochlorhydria and achlorhydria Quantification of gastric acid secretion Factors affecting gastric acid secretion Low -acid states Clinical relevance of gastrin levels and PPI therapy Pepsin History of pepsinogen Properties ofpepsinogen Pepsinogen Regulation of secretion Miscellaneous agents Significance of pepsinogen Intrinsic Factor . Historical issues . Cobalamin Intrinsic factor Cobalamin absorption Regulation of Growth of Gastric Epithelium . Introduction Cell growth in the stomach Growth receptors in gastric mucosa . Keratinocyte growth factor Epithelial restitution Mucosal healing and trefoil peptides Interference with gastric healing Gastric and Duodenal Ulcer Disease History Introduction Early management of peptic ulcer disease . Gastric surgery Surgery of the vagus Peptic Ulcer Disease General Pathogenesis Diagnosis Medical management . Complications of peptic ulcer disease Hypergastrinemia Gastric Carcinoid H istology D evelopm ent Experimental model Mastomys natalensis . Clinical considerations Dyspepsia Non-ulcer dyspepsia Dyspepsia and heartburn Intravenous Anti-Secretory Therapy Introduction Evolution of intravenous access Therapeutic infusion of fluid Blood as intravenous therapy Intravenous medication Acute control of acid secretion Intravenous therapy Cliical aspects of intravenous acid suppression Gastroesophageal Reflux Disease Evolution of the Disease and Its Management . Introduction Ye meri or ysopaghus The etymology of symptomatotlogy Esophagitis The Beatitude of Barrett . Asher Winkelstein . Hiatus hernia The evolution of surgical strategies Nissen and fundoplication Belsey of Bristol Surgery redivivus-laparoscopy Pediatric issues . Current status Etiology Biology The esophageal epithelium Esophageal anatomy and physiology Gastroesophageal junction The lower esophageal sphincter . Physiology and Functional Studies Esophageal function testing Pathophysiology Management Lower esophageal sphincter Afnction in gastroesophageal reflux disease Therapeutic targets Gastric acidity Gastroesophageal reflux disease and esophageal pH F Helicobacter pylo Determination of gastroesophageal reflux disease and management Economics Acute-phase gastroesophageal reflux disease treatment Maintenance treatment of gastroesophageal reflux disease Barrett's Malignant transformation of the esophageal epithelium Bnarrett esophagus Barrett's esophagus and adenocarcinoma Management guidelines Summation Consensus Managempent consensus Definitions and symptoms Pathophysiology Barrett's esophagus Medical therapy Nonmedical therapy Helicobacter pylorin Conclusion Helicobacter pylorin. H-istory Introduction Early bacteriology Early data on gastric bacteriology Twentieth century Ammonia and gastric urease Discovery of Helicobacter pylori and its etiologic role in peptic ulcer Biologic Basis of Gastric Colonization by Helicobacter . Introduction The nature of Helicobacter pylori Acid and Helicobacter pylori Effects of acute changes of medium pH Metabolism as a function of medium pH Acid-adaptive mechanisms in Helicobacter pylori Pathogenesis Infection and Its Consequences Gastric acid secretion after infection Helicobacter pylori and its gastric environment . Mucosal-associated lymphoid tissue lymphoma Diagnosis Relevance as a disease entity Epidemiology Treatment The Twenty-First Century