TY - BOOK AU - Arias,Irwin M. AU - Boyer,J.L. TI - The liver: biology and pathobiology SN - 0781723906 U1 - 612.35 21 PY - 2001/// CY - Philadelphia PB - Lippincott Williams & Wilkins KW - Liver KW - Physiology KW - Pathophysiology KW - pathology KW - physiology N1 - Contents INTRODUCTION Organizational Principles Embryonic Development of the Liver THE CELLS Gap and Tight Junctions in Liver :Composition, Regulation, and Function Motor Molecules Gene Regulation and In Vivo Function of Liver Transcription Factors The Hepatocyte Plasma Membrane:Organization, Differentiation, Biogenesis,and TurnoverHepatocyte Basolateral Membrane Organic Anion Transporters The Hepatocyte Surface:Dynamic Polarity The Endoplasmic Reticulum and Golgi Complex in Secretory Membrane Transport Molecular Mechanisms of Hepatocellular Vesicle Formation Receptor-Mediated Endocytosis Peroxisomal Assembly, Biology, and Disease Relationship SECTION A: HEPATOCYTE:METABOLISM Integrated Cell Function:Apoptosis Fundamentals of Cellular Osmoregulation Roles of Intracellular Proteolysis in Hepatocyte Cell-Cycle,Aging, and Programmed Cell Death Regulation of Hepatic Cholesterol Homeostasis Leptin and the Liver Hypoxic, Ischemic, and Reperfusion Injury to LiverProtective Mechanisms Against Reactive oxygen Species Disorders of Bilirubin Metabolism The Porphyrias Copper Metabolism and the LiverThe Liver and Iron SECTION B:BILE SECRETION The Biology of the Bile Canaliculus Conjugate Export Pumps of the Multidrug Resistance Protein (MRP) Family in Liver Genetic Defects of Canalicular Transport Hormonal Regulation of Bile Secretion Nucleotide Transport and Regulation of Bile Formation The Pathobiology of Biliary Epithelia SECTION C:SINUSOIDAL CELLS Endothelial and Pit Cells Hepatic Stellate Cells:Morphology, Function, and Regulation SECTION D:EXTRACELLULAR MATRIX The Extracellular Matrix of the LiverIntegrins INTERRELATED CELL FUNCTIONS Role of Inositol Trisphosphate and Diacylglycerol in the Regulation of Liver Function Synthesis of an Signaling Through D-3 Phosphoinositides Insulin and Other Growth Factors Cyclic AMP Signaling in the Liver:Coupling Transcription to Psysiology and Proliferation CA2+ Signaling in the Liver Nitric Oxide in the Liver Interleukin-6 Signaling During the Acute-Phase Response of the LiverInnate Immune Sensing and the Toll-Like ReceptorsLiver Regeneration Hepatocyte Growth Factor:Its Role in Hepatic Growth and Pathobiology THE ORGANRELATION TO OTHER ORGANS Hepatic Encephalopathy Alterations of the Kidney in Liver Disease PATHOBIOLOGIC ANLYSISMolecular Pathophysiology of Membrane Transport Function in Cholestasis The Biology of Portal Hypertension 1-Antitrypsin Deficiency Pathophysiology of Liver Fibrosis Alcoholic and Nonalcoholic SteatohepatitisSchistosomiasis:A Model of Immunologically Mediated Liver Disease Immune Mechanisms of Viral Clearance, and Disease Pathogenesis During Viral Hepatitis Epidemiology, Natural History, and Prevention of Viral Hepatitis Molecular Bases of Hepatitis B and Hepatitis C Related Chronic Liver DiseaseMolecular Biology of Hepatitis Viruses Liver Transplantation:Factors Affecting the Balance Between Tolerance and Rejection in Experimental Models Viral Hepatitis:Antiviral Therapy HORIZONS Tissue Engineering of the Liver A Genomic View of Hepatology; Includes bibliographical references and index UR - http://www.loc.gov/catdir/enhancements/fy0809/00069996-d.html ER -