TY - BOOK AU - McCance,Kathryn L. AU - Huether E.Sue AU - Brashers .L vALENTINA AU - Neal .s Rote TI - Understanding pathophysiology SN - 9781771721172, 9780323354097 AV - QT 104 T22u 2017 PY - 2017/// CY - St. Louis, Mo. PB - Elsevier KW - Physiology, Pathological KW - Nurses N1 - Includes Index: 1119-1150; CONTENT Part One Basic Concepts of Pathophysiology Unit 1 The Cell 1 Cellular Biology Prokaryotes and Eukaryotes Cellular Functions Structure and Function of Cellular Components Cell-to-Cell Adhesions Cellular Communication and Signal Transduction Cellular Metabolism Membrane Transport: Cellular Intake and Output Cellular Reproduction: The Cell Cycle Tissues 2 Genes and Genetic Diseases DNA, RNA, and Proteins: Heredity at the Molecular Level Chromosomes Elements of Formal Genetics Transmission of Genetic Diseases Linkage Analysis and Gene Mapping Multifactorial Inheritance 3 Epigenetics and Disease Epigenetic Mechanisms Epigenetics and Human Development Genomic Imprinting Inheritance of Epigenetic States Epigenetics and Cancer Future Directions 4 Altered Cellular and Tissue Biology Cellular Adaptation Cellular Injury Manifestations of Cellular Injury: Accumulations Cellular Death Aging and Altered Cellular and Tissue Biology Somatic Death 5 Fluids and Electrolytes, Acids and Bases Distribution of Body Fluids and Electrolytes Alterations in Water Movement Sodium, Chloride, and Water Balance Alterations in Sodium, Chloride, and Water Balance Alterations in Potassium and Other Electrolytes Acid-Base Balance Pediatric Considerations Geriatric Considerations Unit 2 Mechanisms of Self-Defence 6 Innate Immunity Human Defence Mechanisms Acute and Chronic Inflammation Wound Healing Pediatric Considerations Geriatric Considerations 7 Adaptive Immunity Third Line of Defence: Adaptive Immunity Antigens and Immunogens Antibodies Immune Response: Collaboration of B Cells and T Cells Cell-Mediated Immunity Pediatric Considerations Geriatric Considerations 8 Infection and Defects in Mechanisms of Defence Infection Deficiencies in Immunity Hypersensitivity: Allergy, Autoimmunity, and Alloimmunity 9 Stress and Disease Historical Background and General Concepts The Stress Response Stress, Personality, Coping, and Illness Geriatric Considerations Unit 3 Cellular Proliferation: Cancer 10 Biology of Cancer Cancer Terminology and Characteristics The Biology of Cancer Cells Clinical Manifestations of Cancer Diagnosis, Characterization, and Treatment of Cancer 11 Cancer Epidemiology Genetics, Epigenetics, and Tissue Incidence and Mortality Trends In Utero and Early Life Conditions Environmental and Lifestyle Factors 12 Cancer in Children and Adolescents Incidence, Etiology, and Types of Childhood Cancer Prognosis Part Two Body Systems and Diseases Unit 4 The Neurological System 13 Structure and Function of the Neurological System Overview and Organization of the Nervous System Cells of the Nervous System The Nerve Impulse The Central Nervous System The Peripheral Nervous System The Autonomic Nervous System Geriatric Considerations 14 Pain, Temperature, Sleep, and Sensory Function Pain Temperature Regulation Sleep The Special Senses Somatosensory Function Geriatric Considerations Geriatric Considerations Geriatric Considerations 15 Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function Alterations in Cognitive Systems Alterations in Cerebral Hemodynamics Alterations in Neuromotor Function Alterations in Complex Motor Performance Extrapyramidal Motor Syndromes 16 Disorders of the Central and Peripheral Nervous Systems and Neuromuscular Junction Central Nervous System Disorders Peripheral Nervous System and Neuromuscular Junction Disorders Tumours of the Central Nervous System 17 Alterations of Neurological Function in Children Development of the Nervous System in Children References Structural Malformations Alterations in Function: Encephalopathies Cerebrovascular Disease in Children Childhood Tumours Unit 5 The Endocrine System 18 Mechanisms of Hormonal Regulation Mechanisms of Hormonal Regulation Structure and Function of the Endocrine Glands Geriatric Considerations 19 Alterations of Hormonal Regulation Mechanisms of Hormonal Alterations Alterations of the Hypothalamic-Pituitary System Alterations of Thyroid Function Alterations of Parathyroid Function Dysfunction of the Endocrine Pancreas: Diabetes Mellitus Alterations of Adrenal Function Unit 6 The Hematological System 20 Structure and Function of the Hematological System Components of the Hematological System Development of Blood Cells Mechanisms of Hemostasis Pediatric Considerations Geriatric Considerations 21 Alterations of Hematological Function Alterations of Erythrocyte Function Myeloproliferative Red Blood Cell Disorders Alterations of Leukocyte Function Alterations of Lymphoid Function Alterations of Splenic Function Hemorrhagic Disorders and Alterations of Platelets and Coagulation 22 Alterations of Hematological Function in Children Disorders of Erythrocytes Disorders of Coagulation and Platelets Neoplastic Disorders Unit 7 The Cardiovascular and Lymphatic Systems 23 Structure and Function of the Cardiovascular and Lymphatic Systems The Circulatory System The Heart The Systemic Circulation The Lymphatic System 24 Alterations of Cardiovascular Function Diseases of the Veins Diseases of the Arteries Disorders of the Heart Wall Manifestations of Heart Disease Shock 25 Alterations of Cardiovascular Function in Children Congenital Heart Disease Acquired Cardiovascular Disorders Unit 8 The Pulmonary System 26 Structure and Function of the Pulmonary System Structures of the Pulmonary System Function of the Pulmonary System Geriatric Considerations 27 Alterations of Pulmonary Function Clinical Manifestations of Pulmonary Alterations Disorders of the Chest Wall and Pleura Pulmonary Disorders 28 Alterations of Pulmonary Function in Children Disorders of the Upper Airways Disorders of the Lower Airways Sudden Unexpected Infant Death Unit 9 The Renal and Urological Systems 29 Structure and Function of the Renal and Urological Systems Structures of the Renal System Renal Blood Flow Kidney Function Tests of Renal Function Pediatric Considerations Geriatric Considerations 30 Alterations of Renal and Urinary Tract Function Urinary Tract Obstruction Urinary Tract Infection Glomerular Disorders Acute Kidney Injury Chronic Kidney Disease 31 Alterations of Renal and Urinary Tract Function in Children Structural Abnormalities Glomerular Disorders Nephroblastoma Bladder Disorders Urinary Incontinence Unit 10 The Reproductive Systems 32 Structure and Function of the Reproductive Systems Development of the Reproductive Systems The Female Reproductive System Structure and Function of the Breast The Male Reproductive System Aging and Reproductive Function 33 Alterations of the Female Reproductive System Abnormalities of the Female Reproductive Tract Alterations of Sexual Maturation Disorders of the Female Reproductive System Disorders of the Female Breast 34 Alterations of the Male Reproductive System Alterations of Sexual Maturation Disorders of the Male Reproductive System References Disorders of the Male Breast Sexually Transmitted Infections Unit 11 The Digestive System 35 Structure and Function of the Digestive System The Gastro-Intestinal Tract Accessory Organs of Digestion Geriatric Considerations 36 Alterations of Digestive Function Disorders of the Gastro-Intestinal Tract Disorders of the Accessory Organs of Digestion Cancer of the Digestive System 37 Alterations of Digestive Function in Children Disorders of the Gastro-Intestinal Tract Disorders of the Liver Gastro-Intestinal Malignancies in Children Unit 12 The Musculo-skeletal and Integumentary Systems 38 Structure and Function of the Musculo-skeletal System Structure and Function of Bones Structure and Function of Joints Structure and Function of Skeletal Muscles Aging and the Musculo-skeletal System 39 Alterations of Musculo-skeletal Function Musculo-skeletal Injuries Disorders of Bones Disorders of Joints Disorders of Skeletal Muscle Musculo-skeletal Tumours 40 Alterations of Musculo-skeletal Function in Children Congenital Defects Bone Infection Juvenile Idiopathic Arthritis Osteochondroses Scoliosis Muscular Dystrophy Musculo-skeletal Tumours Nonaccidental Trauma 41 Structure, Function, and Disorders of the Integument Structure and Function of the Skin Disorders of the Skin Disorders of the Hair Disorders of the Nail Geriatric Considerations 42 Alterations of the Integument in Children Acne Vulgaris Dermatitis Infections of the Skin Insect Bites and Parasites Cutaneous Hemangiomas and Vascular Malformations Other Skin Disorders Index ER -