Principles of bone biology /
edited by John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan.
- 2nd edition.
- San Diego : Academic Press, c2002.
- xxiv, 882 p. : ill. ; 29 cm.
- vol. 1 ; vol. 2. .
Contents;
Volume one 1. Basic principles A. Cell biology Structure and development of the skeleton Biomechanics Embryonic development of bone and the molecular regulation and endochondral bone formation Mesenchymal stem cells and osteoblast differentiation Transcriptional control of osteoblast differentiation and function etc.
B. Biochemistry Type I collagen: Structure, synthesis and regulation Collagen cross-linking and metabolism Bone matrix proteoglycans Osteopontin Bone proteinases Integrins and other cell surface attachment molecules of bone cells etc.
C. Bone remodeling and mineral homeostasis Histomorphometric analysis of bone remodeling Phosphorus homeostasis and related disorders Magnesium homeostasis Metals in bone: Aluminum, boron, cadmium, chromium, lead, silicon and strontium etc.
D. The hormones of bone Receptors for parathyroid hormone(PTH) and PTH-related peptide Parathyroid hormone: Molecular biology Parathyroid hormone: Receptor interactions etc.
Volume two Vascular endothelial growth factors Transforming growth factor Bone morphogenetic proteins Bone morphogenetic protein receptors and actions etc.
2. Molecular mechanisms of metabolic bone diseases Molecular basis of PTH overexpression Familial benign hypocalciuric hypercalcemia and neonatal primary hyperparathyroidism Multiple endocrine neoplasia type I etc.
3. Pharmacological mechanisms of therapeutic Parathyroid hormone Calcium Calcium receptors as novel drug targets Bisphosphonates mechanisms of action Fluoride in osteoporosis etc.
4. Methods in bone research Application of transgenic mice to problems of skeletal biology Use of cultured osteoblastic cells to identify and characterize transcriptional regulatory complexes Current methodologic issues in cell tissue culture Biochemical markers of bone metabolism etc.