Molecular diagnostics / edited by George P. Patrinos, Wilhelm Ansorge.

Includes bibliographical references and index.

Contents

Section 1. Molecular diagnostic technology
Chapter 1.Molecular Diagnostics: Past, Present and Future
Chapter 2.Allele-Specific Mutation Detection By PCR-ARMS And PCR-ASO
Chapter 3.Competitive Oligopriming
Chapter 4.Oligonucleotide Ligation Assays for the Diagnosis of Inherited Diseases
Chapter 5.Enzymatic and Chemical Cleavage Methods to Identify Genetic Variation
Chapter 6.Mutation Detection by Single Strand Conformation Polymorphism and Heteroduplex Analysis
Chapter 7.Capillary Electrophoresis
Chapter 8.Temperature and Denaturing Gradient Gel Electrophoresis
Chapter 9.Two-Dimensional Gene Scanning
Chapter 10.Real-Time Polymerase Chain Reaction
Chapter 11.Pyrosequencing
Chapter 12.Molecular Cytogenetics In Molecular Diagnostics
Chapter 13.Detection of Genomic Duplications and Deletions
Chapter 14.Analysis of Human Splicing Defects Using Hybrid Minigenes
Chapter 15.DNA Microarrays and Genetic Testing
Chapter 16.Human Genome Microarray In Biomedical Applications
Chapter 17.Use of High Throughput Mass Spectrographic Methods To Identify Disease Processes
Chapter 18.The Application of Proteomics To Disease Diagnostics

Section 2: Applications of molecular diagnosis and related issues
Chapter 19.Identification of Genetically Modified Organisms
Chapter 20.Pharmacogenetics and Pharmacogenomics: Impact on Drug Discovery and Development
Chapter 21.Molecular Diagnostic Applications in Forensic Science
Chapter 22.Molecular Diagnostics and Comparative Genomics in Clinical Microbiology
Chapter 23.Preimplantation Genetic Diagnosis
Chapter 24.Genetic Monitoring of Laboratory Animals
Chapter 25.The Use of Locus-Specific Databases in Molecular Diagnostics
Chapter 26.Safety Analysis in Retroviral Gene Therapy: Identifying virus integration sites in gene-modified cells
Chapter 27.Automated DNA Hybridisation and Detection
Chapter 28.The Use of Microelectronic-Based Techniques in Molecular Diagnostic Assays
Chapter 29.Miniaturization technologies for molecular diagnostics
Chapter 30.Human Gene Patents and Genetic Testing
Chapter 31.Genetic Counseling and Ethics in Molecular Diagnostics
Chapter 32.Genetic Testing and Psychology
Chapter 33.Safety in Biomedical and Other Laboratories
Chapter 34.Quality Management in the Laboratory